Transpulmonary Thermodilution Measurements in Patients With Heart Diseases

Launched by UNIVERSITY OF ZURICH · Jan 10, 2014

Keywords

ClinConnect Summary

* How do PiCCO and PAC (pulmonary artery catheter) derived hemodynamic variables change in different cardiac pathologies?
* How do PiCCO hemodynamic variables compare to transthoracic echocardiographic parameters in different cardiac pathologies?
* How does GEDV (global enddiastolic volume) correlate with left ventricles end-diastolic volume (LVEDV) assessed by LV (left ventricle) ventriculography and echocardiography?
* How do PiCCO cardiac function variables (GEF \[global ejection fraction\]; CFI \[cardiac function index\]) correlate with LV dP/dt max, LVEF (left ventricular ejection frac...

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Eligibility criteria

• Inclusion criteria:
• • Coronary heart disease without impaired left ventricular function \[LV-EF \> 50%\] (n=10, control group)
• • Coronary heart disease with impaired left ventricular function \[LV-EF \< 50%\] (n=10)
• • Dilated cardiomyopathy (n=10),
• • Aortic valve stenosis (n=10),
• • Mitral valve regurgitation (n=10),
• • Diastolic left ventricular dysfunction (n=10) and
• • Right heart failure (n=10)
• Exclusion criteria:
• • Patients with catecholamine dependent cardiogenic shock, severe respiratory distress because of pulmonary oedema, intubated patients, patients with atrial fibrillation, atrioventricular conduction abnormalities, and slow ventricular tachycardia will not be included.
• • Moreover patients not being able to give informed consent are excluded. Even more, pregnant women are excluded from the study due to the radiation exposure in line with heart catheterization. A pregnancy test will be performed prior to participating with this study.
• • The age does not represent an exclusion criterion.