Identification of Phenotypic Factors That Predict Success for Weight Loss and Long-term Weight Maintenance

Launched by UNIVERSITY OF MICHIGAN · Jan 21, 2014

Keywords

ClinConnect Summary

This clinical trial, called the Weight Management Program at the University of Michigan, is studying how different factors can help people lose weight and keep it off in the long term. Researchers believe that a personalized approach is better than a "one-size-fits-all" method for managing obesity, which is a complex condition. The program offers participants the chance to choose standard care or take part in various studies focusing on nutrition, the science behind weight, and treatments that include both approved and experimental medications.

To be eligible for this trial, you need to be over 20 years old and have a body mass index (BMI) of 27 or higher, which means you are considered obese. If you have a lower BMI but still meet certain criteria, you may also qualify. Participants can expect to receive tailored support and access to different resources to help with weight management. However, there are some health conditions that would prevent someone from joining the study, like certain cancers, uncontrolled thyroid issues, or severe heart problems. If you think you might be interested in participating, it's a good idea to talk to your doctor for more information.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Obese males and females: age \>20 years; Obese population defined as BMI \> or = 27 kg/m2
• • Lean population BMI \< 27 but \> 17 kg/m2
• • Able and willing to provide written informed consent for the trial
• Exclusion Criteria:
• • Evidence of inherited disorders of lipid metabolism.
• • History of Cancer within the last 5 years
• • Human immunodeficiency virus (HIV) antibody positive.
• • Patients with solid organ transplants.
• • Participation in any other clinical trial within 90 days of entry into this trial.
• • Pregnant or lactating females.
• • Uncontrolled thyroid disease
• • Unstable angina or NY heart association class II failure or above
• • Gastrointestinal disease specifically GI motility disorders
• • Unstable neuropsychiatric disease including major depression/anxiety, eating disorder such as binge eating, bulimia or anorexia
• • End stage renal or hepatic disease
• • Autoimmune disorders (e.g. SLE)
• • Body weight fluctuation of more than 5 kg in the previous 3 months
• • Prior bariatric surgery
• • A history or current alcohol/substance abuse and change in smoking habits or cessation in the past 6 months.
• • Women of childbearing age must use a reliable form of contraception.
• • Any medical condition, which in the opinion of the investigator would make the patient unsuitable for recruitment, or could interfere with the patient participating in or completing the protocol.
• • Unwilling or unable to consent for the study.