L-Cysteine in Peritoneal Dialysis

Launched by MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH · Jan 29, 2014

Keywords

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Males and females aged ≥ 18 years;
• • Chronic automated peritoneal dialysis;
• • Residual 24-hour diuresis ≥ 100 ml with less than 30% changes over the three months preceding randomization;
• • Written informed consent.
• Exclusion Criteria:
• • Chronic automated peritoneal dialysis therapy since less than three months;
• • Diabetes mellitus;
• • Acute peritonitis during the three months before enrollment;
• • Concomitant treatment with other antioxidant agents (including N-acetyl-cysteine and vitamin C);
• • Cystinuria;
• • Pregnancy or breastfeeding;
• • Childbearing potential without reliable contraceptive methods during the whole study period;
• • Alcohol or drug (excluding tobacco) abuse;
• • Inability to comply with the study procedures during the whole study period, legal incapacity;
• • Cancer and any severe systemic disease or clinical condition that may jeopardize data interpretation or completion of the study.