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Search / Trial NCT02098252

Treatment of Brain AVMs (TOBAS) Study

Launched by CENTRE HOSPITALIER DE L'UNIVERSITÉ DE MONTRÉAL (CHUM) · Mar 25, 2014

Trial Information

Current as of August 26, 2025

Recruiting

Keywords

Brain Arteriovenous Malformation Arteriovenous Malformations Avm Bavm Stroke Intracranial Hemorrhage Congenital Abnormalities Aneurysm Vascular Malformations Cardiovascular Abnormalities Cardiovascular Diseases Vascular Diseases

ClinConnect Summary

The TOBAS Study is researching the best ways to treat brain arteriovenous malformations (AVMs), which are abnormal connections between blood vessels in the brain. This study aims to find out if medical management or certain treatments, like surgery or radiation, can lower the risk of death or serious stroke in patients with unruptured AVMs. They hope to see a significant improvement in safety and effectiveness when using endovascular procedures, which involve guiding a small tube through blood vessels to treat the AVM.

To participate in this study, you need to be at least 18 years old and have a brain AVM. However, if you are experiencing severe symptoms from a bleeding AVM that requires immediate surgery, you won’t be eligible. If you join the trial, you will receive careful monitoring and treatment options tailored to your situation. The study is currently looking for participants, and everyone’s involvement could help improve future treatments for this condition.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Any patient with a brain AVM
  • Exclusion Criteria:
  • Hemorrhagic presentation with mass effect requiring surgical management. In these cases, if a residual AVM is found after the initial surgery, the patient could then be a candidate for TOBAS.

About Centre Hospitalier De L'université De Montréal (Chum)

The Centre Hospitalier de l'Université de Montréal (CHUM) is a leading academic health institution in Canada, dedicated to advancing patient care through innovative research and clinical excellence. As a prominent sponsor of clinical trials, CHUM is committed to leveraging its multidisciplinary expertise and state-of-the-art facilities to facilitate groundbreaking studies that enhance medical knowledge and improve health outcomes. Collaborating with a network of healthcare professionals and researchers, CHUM fosters a rigorous research environment that prioritizes patient safety, ethical standards, and scientific integrity, positioning itself at the forefront of medical advancements.

Locations

Boston, Massachusetts, United States

Edmonton, Alberta, Canada

Rennes, , France

Edmonton, Alberta, Canada

Albuquerque, New Mexico, United States

Caen, , France

Limoges, , France

Nantes, , France

Montreal, Quebec, Canada

Clermont Ferrand, , France

Bordeaux, , France

Paris, , France

Jacksonville, Florida, United States

Fortaleza, , Brazil

São Paulo, , Brazil

Santiago, , Chile

Brest, Bretagne, France

Besançon, , France

Dijon, , France

Le Kremlin Bicêtre, , France

Lyon, , France

Marseille, , France

Montpellier, , France

Nancy, , France

Paris, , France

Paris, , France

Rouen, , France

Strasbourg, , France

Toulouse, , France

Tours, , France

Montreal, Quebec, Canada

Bucaramanga, , Colombia

Patients applied

0 patients applied

Trial Officials

Daniel Roy, MD

Principal Investigator

CHUM-Montreal

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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