Treatment of Brain AVMs (TOBAS) Study
Launched by CENTRE HOSPITALIER DE L'UNIVERSITÉ DE MONTRÉAL (CHUM) · Mar 25, 2014
Trial Information
Current as of August 26, 2025
Recruiting
Keywords
ClinConnect Summary
The TOBAS Study is researching the best ways to treat brain arteriovenous malformations (AVMs), which are abnormal connections between blood vessels in the brain. This study aims to find out if medical management or certain treatments, like surgery or radiation, can lower the risk of death or serious stroke in patients with unruptured AVMs. They hope to see a significant improvement in safety and effectiveness when using endovascular procedures, which involve guiding a small tube through blood vessels to treat the AVM.
To participate in this study, you need to be at least 18 years old and have a brain AVM. However, if you are experiencing severe symptoms from a bleeding AVM that requires immediate surgery, you won’t be eligible. If you join the trial, you will receive careful monitoring and treatment options tailored to your situation. The study is currently looking for participants, and everyone’s involvement could help improve future treatments for this condition.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Any patient with a brain AVM
- Exclusion Criteria:
- • Hemorrhagic presentation with mass effect requiring surgical management. In these cases, if a residual AVM is found after the initial surgery, the patient could then be a candidate for TOBAS.
About Centre Hospitalier De L'université De Montréal (Chum)
The Centre Hospitalier de l'Université de Montréal (CHUM) is a leading academic health institution in Canada, dedicated to advancing patient care through innovative research and clinical excellence. As a prominent sponsor of clinical trials, CHUM is committed to leveraging its multidisciplinary expertise and state-of-the-art facilities to facilitate groundbreaking studies that enhance medical knowledge and improve health outcomes. Collaborating with a network of healthcare professionals and researchers, CHUM fosters a rigorous research environment that prioritizes patient safety, ethical standards, and scientific integrity, positioning itself at the forefront of medical advancements.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Boston, Massachusetts, United States
Edmonton, Alberta, Canada
Rennes, , France
Edmonton, Alberta, Canada
Albuquerque, New Mexico, United States
Caen, , France
Limoges, , France
Nantes, , France
Montreal, Quebec, Canada
Clermont Ferrand, , France
Bordeaux, , France
Paris, , France
Jacksonville, Florida, United States
Fortaleza, , Brazil
São Paulo, , Brazil
Santiago, , Chile
Brest, Bretagne, France
Besançon, , France
Dijon, , France
Le Kremlin Bicêtre, , France
Lyon, , France
Marseille, , France
Montpellier, , France
Nancy, , France
Paris, , France
Paris, , France
Rouen, , France
Strasbourg, , France
Toulouse, , France
Tours, , France
Montreal, Quebec, Canada
Bucaramanga, , Colombia
Patients applied
Trial Officials
Daniel Roy, MD
Principal Investigator
CHUM-Montreal
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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