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Search / Trial NCT02104336

Phase 2 Study of EPI-743 in Children With Pearson Syndrome

Launched by EDISON PHARMACEUTICALS INC · Apr 3, 2014

Trial Information

Current as of July 16, 2025

Terminated

Keywords

Pearson Epi743 Epi 743 Vincerinone Mitochondrial Disorder Mitochondrial Disease

ClinConnect Summary

If effective, treatment with EPI-743 should result in a significant reduction in occurrence of sepsis, metabolic crisis, hepatic failure and transfusion dependence.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Genetically confirmed diagnosis of Pearson syndrome
  • Age less than 18
  • Availability of medical history for 12 months prior to enrollment
  • Abstention from use of CoQ10, vitamin E, lipoic acid and Idebenone 14 days prior to treatment with EPI-743
  • Exclusion Criteria:
  • Allergy to EPI-743, sesame oil or vitamin E
  • Clinical history of bleeding/ abnormal PT/PTT
  • Concurrent inborn errors of metabolism
  • Use of anticoagulant medications
  • Participation in any interventional study within 30 days of treatment
  • Use of erythropoietin 30 days prior to trial enrollment

About Edison Pharmaceuticals Inc

Edison Pharmaceuticals Inc. is a biopharmaceutical company dedicated to advancing innovative therapies for the treatment of rare and complex diseases, particularly those related to mitochondrial dysfunction. With a focus on developing targeted drug candidates that address unmet medical needs, Edison combines cutting-edge scientific research with a commitment to patient-centric solutions. The company leverages a robust portfolio of proprietary compounds and collaborates with leading researchers and institutions to drive clinical development and bring transformative treatments to market. Through its rigorous clinical trial programs, Edison Pharmaceuticals aims to improve the quality of life for patients and their families affected by debilitating conditions.

Locations

Houston, Texas, United States

Orange, California, United States

Cleveland, Ohio, United States

Pittsburgh, Pennsylvania, United States

Patients applied

0 patients applied

Trial Officials

Matthew Klein, MD, FACS

Study Chair

Edison Pharmaceuticals

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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