Phenotypes of COPD in Central and Eastern Europe

Launched by ZUZANA ZBOŽÍNKOVÁ, M.SC. · Apr 18, 2014

Keywords

ClinConnect Summary

Chronic Obstructive Pulmonary Disease (COPD) is a significant cause of morbidity and mortality in Europe and a major consumer of resources in both primary and secondary healthcare (1,2). Both clinical features of disease severity and quality of COPD patient care may have substantial influence on disease outcomes. Traditionally, COPD has been categorized using the FEV1 (forced expiratory volume at one second ) - based GOLD (The Global Initiative for Chronic Obstructive Lung Disease) classification . Other factors independently associated with survival include age, dyspnoea, health status, hy...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • 1. Age \> 40 years
• • 2. Clinical diagnosis of COPD with post-bronchodilator FEV1/FVC \< 0.7
• • 3. Smoking burden ≥ 10 pack-years in smokers (group A). Evidence of exposure to at least one other typical inhaled COPD risk factor: environmental tobacco smoke, professional exposures, etc. (group B) Each country will include 300 COPD subjects with positive history of smoking (at least 10 pack-years). Consecutive non-smokers with COPD can be enrolled above this limit. Institute for Biostatistics and Analyses, Masaryk University, Brno, The Czech Republic will analyze both COPD groups (A and B) separately
• • 4. Stable disease for at least 4 weeks
• • 5. Outpatient status
• • 6. Informed Consent
• Exclusion Criteria:
• • 1. Exacerbation of COPD and/or instable co-morbid condition
• • 2. Patient during hospital stay for whatever reason (lung or co-morbidities)
• • 3. Patient is not able and willing to participate