OCT in Rare Chorioretinal Diseases

Launched by OREGON HEALTH AND SCIENCE UNIVERSITY · May 16, 2014

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how certain rare eye diseases affect blood flow in the retina and choroid, which are important parts of the eye. Researchers will use a special imaging technique called Doppler optical coherence tomography (OCT) to measure blood flow. The goal is to see if these diseases change blood flow compared to healthy eyes and if these changes match areas of damage seen in other eye tests. This study is currently looking for participants aged 25 to 65 who have been diagnosed with conditions affecting the retina or choroid.

To participate, individuals must be able to provide informed consent and complete the study tests within 30 days. However, those with certain health issues, like severe kidney disease or unstable medical conditions, and those who are pregnant or breastfeeding cannot join. Participants can expect to undergo eye imaging tests that are non-invasive and will help researchers gather important information about their eye health. This study could contribute to better understanding and treatment options for rare eye diseases.

Gender

ALL

Eligibility criteria

• Subject-Level Criteria:
• • Inclusion a. Diagnosis of retinal or choroidal disease
• • Exclusion
• • 1. Inability to give informed consent.
• • 2. Inability to complete study tests within a 30 day period
• • 3. Significant renal disease, defined as a history of chornic renal failure requiring dialysis or kidney transplant.
• • 4. A condition that, in the opinion of the investigator, would preclude participation in the study (e.g. unstable medical status including blood pressure, cardiovascular disease, and glycemic control).
• • 5. Blood pressure \> 180/110 (systolic above 180 OR diastolic above 110). If blood pressure is brought below 180/110 by anti-hypertensive treatment, subject can become eligible.
• • 6. Women of child-bearing potential: pregnant or lactating or intending to become pregnant within the next 12 months due to unknown safety of fluorescein angiography.
• Study-Eye Criteria:
• • Inclusion
• • a. Diagnosis of retinal or choroidal disease
• • Exclusion
• • 1. Inability to maintain stable fixation for OCT imaging.
• • 2. An ocular condition is present that, in the opinion of the investigator, might affect or alter visual acuity during the course of the study (i.e. cataract)
• • 3. Substantial cataract that, in the opinion of the investigator, is likely to decrease visual acuity by 3 lines or more (i.e. cataract would be reducing acuity to 20/40 or worse if the eye was otherwise normal).
• • 4. Media opacity or otherwise that would prevent either fixation or ability to obtain adequate images as determined by the examiner.