Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors

Launched by NATIONAL CANCER INSTITUTE (NCI) · May 20, 2014

Keywords

ClinConnect Summary

This clinical trial is focused on understanding different types of lung cancer and related tumors by collecting tissue samples from patients. Researchers hope that by studying these samples, they can learn more about how these cancers develop and find better ways to diagnose and treat them. The study is open to adults aged 18 and older who have been diagnosed with non-small cell lung cancer, small cell lung cancer, extrapulmonary small cell cancer, pulmonary neuroendocrine tumors, or thymic epithelial tumors.

If you choose to participate, you will first undergo some basic health evaluations, which may include a physical exam, blood tests, and a review of your medical history. You might also be asked to provide urine or saliva samples and a tissue sample from a previous biopsy. Additionally, you may have imaging tests, like MRIs or CT scans, to help researchers understand your condition better. After your visits, the study team will check in with you by phone each year to see how you’re doing. This study is currently recruiting participants, and it’s a chance to contribute to important research that could help others facing similar health challenges.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • Individuals with histologically or cytologically confirmed NSCLC, SCLC, ESCC, PNET, and TET.
• • Individuals consulted in the Clinical Center without a definitive diagnosis, but clinically considered likely to have a malignancy of the above histologies, pending further tissue acquisition and/or pathology review.
• • Age greater than or equal to18 years. Children are excluded from the study, as the above thoracic malignancies are rare in this population.
• • Ability of subject to understand and the willingness to sign a written informed consent document.
• EXCLUSION CRITERIA:
• • Active symptomatic major organ disorder that would increase the risk of biopsy, including but not limited to ischemic heart disease, recent myocardial infarction, active congestive heart failure, pulmonary dysfunction.
• • Active concomitant medical or psychological illnesses that may increase the risk to the subject, at the discretion of the Principal Investigator.
• • Known HIV-positive individuals not on combination antiretroviral therapy are ineligible.