Blood Samples for the Study of Peanut, Tree Nut and Other Food Allergies

Launched by UNIVERSITY OF COLORADO, DENVER · Jul 16, 2014

Keywords

ClinConnect Summary

This clinical trial is focused on understanding food allergies, specifically peanut and tree nut allergies. Researchers are collecting blood samples from people with these allergies as well as from those without allergies. By studying these samples, they aim to develop new lab tests to predict the severity of allergic reactions to peanuts, identify the specific parts of peanuts that trigger allergies, find ways to prevent these allergies, and explore the strongest proteins in walnuts.

To participate, individuals aged 1 to 75 may be eligible if they have a known peanut or tree nut allergy, have undergone a specific type of treatment called Oral ImmunoTherapy, or have no allergies at all. Participants will not need to provide any personal information, and the blood samples will help advance research in food allergies, potentially leading to better treatments and prevention strategies in the future.

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Eligibility criteria

• Inclusion Criteria:
• • This protocol is to draw blood for a variety of related studies of food allergy. For this reason, we will list each group of subjects and the inclusion criteria for that group.
• • 1. De-identified sera or plasma from patients who have undergone Oral ImmunoTherapy (OIT) for peanut allergy. These samples already exist.
• * Inclusion criteria:
• • 1. patients have been enrolled in a controlled trial of OIT for peanuts, and had at least one oral challenge.
• • 2. Age 1-75.
• • 2. De-identified samples from patients who are undergoing clinically indicated food challenges for peanut allergy.
• * Inclusion criteria:
• • 1. concern regarding possible allergy to peanuts,
• • 2. age 1-75,
• • 3. plan to undergo a clinically indicated challenge with peanuts.
• • 3. Patients with peanut allergy.
• * Inclusion criteria:
• • 1. excellent history of a systemic reaction to peanuts,
• • 2. age 6-75.
• • 4. Patients with other food allergies (especially tree nuts).
• * Inclusion criteria:
• • 1. excellent history of a systemic reaction to tree nuts or other foods,
• • 2. age 6-75.
• • 5. Normal controls.
• * Inclusion criteria:
• • 1. no known food allergies,
• • 2. recent ingestion of peanuts without difficulty, and
• • 3. age 6-75.
• Exclusion Criteria:
• • 1. Any known significant medical or psychiatric diagnosis
• • 2. Use of an investigational drug within 30 days
• • 3. Use of omalizumab (anti-IgE; Xolair) within 6 months