Reversal of Lipid-Induced Insulin Resistance

Launched by YALE UNIVERSITY · Jul 16, 2014

Keywords

ClinConnect Summary

This clinical trial is exploring whether losing weight can help improve insulin sensitivity in individuals who are insulin resistant and have a family history of type 2 diabetes. Insulin resistance means the body doesn’t respond well to insulin, which can lead to high blood sugar levels and potentially diabetes. The study will measure how weight loss affects fat stored in muscles and the liver, which are important for insulin function.

To participate in this study, you should be a healthy adult aged 18 to 75, who does not smoke and is not taking any medications except for birth control. You should not have any diseases, especially diabetes, and should not have a history of eating disorders. Participants will engage in some assessments, including a three-hour test to check how their body processes different substances. It’s important to note that those who regularly exercise or have certain health conditions will not be eligible to participate. If you meet the criteria and are interested, this study could provide valuable insights into improving insulin sensitivity through weight loss.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy, sedentary, non-smoking and not taking any medications other than birth control pills.
• • Hematocrit \>35%
• • Subjects will have no systemic or organ disease including diabetes.
• • Subjects will have no history eating disorders.
• • Women must be using a form of birth control (sexual abstinence, birth control pills, Norplant, IUD or condoms) and will be studied between day 0 and 7 of their menstrual cycle.
• • Those who are taking birth control pills or have had a hysterectomy may be studied at any time.
• • Physical activity will be assessed using a standard questionnaire with an activity index cut off at 2.3.
• Exclusion Criteria:
• • Any subject, who does not fit the inclusion criteria. Including history of eating disorders, any systemic and organ disease including diabetes.
• • Lactose intolerance Any blood count, clotting abnormalities HYpertriglyceridemeia (TG over 100 mg/dL)
• • Hematocrit \<35%.
• • Women of childbearing potential, who are not using contraception (as mentioned above) or who are not abstinent.
• • Subjects who have a regular exercise regimen will not be enrolled.
• • Metal implants and/or body piercing, which cannot be removed before the MR studies.