Comparison of MEOPA + Paracetamol Versus Morphine Treatment in Acute Coronary Syndrome Analgesia.

Launched by UNIVERSITY HOSPITAL, TOULOUSE · Jul 22, 2014

Keywords

ClinConnect Summary

The investigators wish to compare the use of morphine according to current recommendations with the use of MEOPA associated with intravenous paracetamol in the management of patients with STEMI. The investigators hypothesize that the association of MEOPA and paracetamol, which is easy to use in a pre-hospital setting, will give patients pain relief as effectively as morphine.

This alternative treatment would avoid the use of morphine, whose potentially damaging consequences on myocardial function have been suggested by experimental studies and by an observational study. The physician of th...

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Eligibility criteria

• Inclusion Criteria:
• • Patient with STEMI \< 12 h treated before hospital admission and pain ≥ 4 on the numerical rating scale.
• Exclusion Criteria:
• • Acute severe hemodynamic, respiratory or neurological failure
• • Heart failure: Killip class III and IV
• • Known allergy to morphine or nitrous oxide
• • Patient who has already received morphine or MEOPA before the arrival of the hospital team during the 4 hours preceding the pre-hospital intervention
• • Contraindications to nitrous oxide
• • Patient unable to assess pain intensity on the numerical rating scale
• • Patient under legal guardianship
• • Pregnancy
• • Patient transported by air ambulance