Imaging the Duodenum Using an Optical Frequency Domain Imaging OFDI Capsule

Launched by MASSACHUSETTS GENERAL HOSPITAL · Jul 25, 2014

Keywords

ClinConnect Summary

Subjects including healthy volunteers as well as patients with Celiac disease will be recruited and asked to swallow the OFDI capsule while being awake and unsedated. The capsule is attached to a tether which allows the operator to control as well as navigate the capsule as it progresses down the esophagus, through the stomach and into the duodenum using natural propulsive force called peristalsis.

As the capsule progresses, multiple 2-dimensional cross sectional images of the duodenum are acquired. Images are analyzed at a later stage.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Subject must be over 18 years for healthy volunteers
• • Subjects must be over 16 years for patients with Celiac disease
• • Subject must be able to give informed consent
• Exclusion Criteria:
• • Subjects with an inability to swallow pills or capsules.
• • Subjects with esophageal or intestinal fistulas.
• • Subjects with known esophageal or intestinal strictures resulting in a luminal diameter smaller than the diameter of the capsule.
• • Subjects with a history of intestinal Crohn's disease.
• • Women who are pregnant.