Study of Depressive Symptoms Predicting Postoperative Cognitive Dysfunction
Launched by UNIVERSITÄTSKLINIKUM HAMBURG-EPPENDORF · Aug 4, 2014
Trial Information
Current as of September 10, 2025
Completed
Keywords
ClinConnect Summary
The aetiology of POCD is multifactorial. One described risk factor is preoperative existing depressive symptoms in patients undergoing cardiac surgery.
A total of 300 consecutive patients and 80 healthy controls will be enrolled in this study. Patients will be followed up at 7 days, 3 months and 1 year postoperatively. The co gnitive function will be tested and compared to tests done before surgery. Postoperatively - from the day of operation until the 7th day (except day 6) - grade of sedation, agitation, signs of delirium, pain, cardiac, respiratory, renal and infectious complications wi...
Gender
ALL
Eligibility criteria
- Inclusion Criteria for patients and healthy controls:
- • Age \> 60 years
- • Written informed patient's consent
- Additional Inclusion Criteria for patients:
- • Elective non-cardiac surgery and non-neurosurgical procedures in general anaesthesia or combined general/regional anaesthesia
- • Minimum of duration of operation 120 minutes
- • Baseline testing 3-14 days preoperatively
- Additional Inclusion Criteria for healthy controls:
- • matched for age, gender and education
- • no surgery over the study period
- Exclusion Criteria for patients and healthy control:
- • German not mother tongue
- • Illiteracy
- • Mental disability
- • Vision impairment not correctable
- • Hearing impairment not correctable
- • Illegal substance abuse (current or past history)
- • Alcohol abuse (current or past history)
- • Chronic benzodiazepine use
- • Psychosis (current or past history)
- • Parkinson Disease
- • Dementia
- • Multiple sclerosis
- • Epilepsy (current or past history)
- • Cerebral tumor (current or past history)
- • Apoplexy or intracranial bleeding (current or past history)
- • Severe traumatic brain injury (current or past history)
- • Severe liver disease (Child Pugh B, C, liver insufficiency)
- • Severe kidney disease with dialysis
- • Mini Mental Status Examination \< 24 points
About Universitätsklinikum Hamburg Eppendorf
Universitätsklinikum Hamburg-Eppendorf (UKE) is a leading academic medical center in Germany, renowned for its commitment to advancing healthcare through innovative research and clinical excellence. As a prominent sponsor of clinical trials, UKE integrates state-of-the-art facilities with a multidisciplinary approach, fostering collaboration among top-tier researchers, clinicians, and healthcare professionals. The institution is dedicated to improving patient outcomes by conducting rigorous scientific investigations that address critical health challenges, ultimately contributing to the development of novel therapies and enhancing medical knowledge.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Hamburg, Germany
Patients applied
Trial Officials
Julia Wiede, MD
Principal Investigator
Department of Anaesthesiology and Intensive Care Medicine, University Hospital Hamburg Eppendorf
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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