Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers

Launched by IMPERIAL COLLEGE LONDON · Aug 20, 2014

Keywords

ClinConnect Summary

This clinical trial is looking at how using MRI (a type of detailed imaging) can help in planning treatment for patients with cancer of the sigmoid colon, which is part of the large intestine. The goal is to see if MRI can provide extra information that improves the treatment decisions made by a team of doctors. Patients who are suspected to have this type of cancer and are eligible for curative treatment may join the study. They will be divided into two groups: one will receive standard care with a CT scan, while the other will have both CT and MRI scans before their surgery.

To participate, patients need to be at least 16 years old and have a suspected or confirmed diagnosis of sigmoid colon cancer that can be treated with surgery. They should not have any other serious health issues or cancer that would prevent them from receiving treatment. If they join the study, participants will be followed up after one and three years to assess their health and quality of life. This trial is currently recruiting participants and aims to gather important information that could lead to better treatment options for patients with this type of cancer.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Have a suspected or proven sigmoid colon adenocarcinoma
• • 2. Is eligible for curative treatment
• • 3. Has no irresectable metastatic disease
• • 4. MRI can be reviewed by an MDT prior to surgery
• • 5. Has no decision regarding radical treatment
• • 6. Have provided written informed consent to participate in the study
• • 7. Be aged 16 years or over
• Exclusion Criteria:
• • 1. Have metastatic disease (including resectable liver metastases)
• • 2. Have a synchronous second malignancy
• • 3. Are contraindicated for MRI
• • 4. Are contraindicated for or have allergy to Buscopan (e.g. glaucoma, small or large bowel obstruction, GFR\<30)
• • 5. Have severe co-morbidities or previous medical history that prevent the application of eventual chemo/radiotherapy