Comparison of Two Anaesthetics on Brain During Brain Tumour Surgery
Launched by UNIVERSITY MEDICAL CENTRE LJUBLJANA · Aug 27, 2014
Trial Information
Current as of August 15, 2025
Completed
Keywords
ClinConnect Summary
Anaesthetic technique for craniotomy has to provide optimal cerebral perfusion, oxygenation and prevent brain oedema (1). It also has to lower the stress response on pain during intubation and surgical manipulation. Emergence from anaesthesia has to be rapid and smooth to permit early postoperative neurological evaluation. The most likely opioid in the last decade is short acting opioid remifentanil that can be easy titrated during the procedure and provides early recovery (2, 3, 4, 5). Currently the propofol-remifentanil and sevoflurane-remifentanil are the most frequently used combination...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • age 18-80 years
- • American Society of Anaesthesiologists (ASA) physical status I-III
- • Scheduled for brain tumour surgery
- • Glasgow Coma Score 15
- • Cooperative
- Exclusion Criteria:
- • No written informed consent
- • Eendocrine systematic disease
- • Ddrugs that alter endocrine metabolism
- • History of drug hypersensitivity
- • Drug addiction
- • Perioperative blood derivatives.
About University Medical Centre Ljubljana
University Medical Centre Ljubljana (UMCL) is a leading academic medical institution in Slovenia, dedicated to advancing healthcare through innovative research and clinical trials. As a prominent sponsor of clinical studies, UMCL integrates cutting-edge medical practices with comprehensive patient care, fostering an environment of collaboration among healthcare professionals, researchers, and patients. With a strong emphasis on ethical standards and scientific integrity, UMCL aims to contribute to the global body of medical knowledge while improving treatment outcomes in various therapeutic areas.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Ljubljana, , Slovenia
Patients applied
Trial Officials
Jasmina Markovic Bozic, MD, MSC
Principal Investigator
CD of Anaesthesiology and Intensive Therapy, University Medical Centre Ljubljan
Blaz Karpe, PHD
Principal Investigator
Faculty of Natural Science and Engineering, University of Ljubljana
Iztok Potocnik, MD, MSC
Principal Investigator
CD of Anaesthesiology and Intensive Therapy, University Medical Centre Ljubljan
Ales Jerin, PHD
Principal Investigator
CLINICAL INSTITUTE OF CLINICAL CHEMISTRY AND BIOCHEMISTRY, University Medical Centre Ljubljana
Andrej Vranič, MD, PHD
Principal Investigator
CD of Neurosurgery, University Medical Centre Ljubljana
Vesna Novak Jankovic, PROF, PHD
Study Chair
CD of Anaesthesiology and Intensive Therapy, University Medical Centre Ljubljana
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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