Use of Ex Vivo Lung Perfusion (EVLP) in Reconditioning Marginal Donor Lungs for Transplantation

Launched by CENTRE HOSPITALIER DE L'UNIVERSITÉ DE MONTRÉAL (CHUM) · Sep 9, 2014

Keywords

ClinConnect Summary

This clinical trial is looking at a new method called Ex Vivo Lung Perfusion (EVLP), which helps improve the quality of donor lungs that might otherwise not be suitable for transplantation. The goal is to see if this technique can safely allow more donor lungs to be used, ultimately increasing the number of successful lung transplants. Researchers will also study certain biological markers during this process to learn more about how lungs respond to inflammation before they are transplanted.

To participate in this trial, you need to be an adult (18 years or older) who is already on the waiting list for a lung transplant and able to give your consent to be part of the study. If you join, you’ll be closely monitored during the process, and you may help improve the understanding of lung transplants for future patients. It's important to note that individuals under 18, those who can't provide consent, or those needing certain types of advanced medical support won't be eligible for this trial. Overall, this study could play a significant role in expanding the possibilities for lung transplantation.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients (aged 18 years and over).
• • Patients already on or added to the active waiting list for first lung transplant.
• • Patients providing informed consent for participation in the study at the time of study commencement or time of listing for transplant.
• • Patients' re-confirmation informed consent for the study on the day of the lung transplant.
• Exclusion Criteria:
• • Patients aged less than 18 years.
• • Patients not providing informed consent for the study.
• • Patients not in possession of patient information sheets for the study prior to the day of lung transplant.
• • Patients' not re-confirming consent for the study on the day of lung transplant.
• • Patients requiring invasive mechanical ventilation, extracorporeal membrane oxygenation (ECMO) support.