Treatment of Muscle Weakness in Critically Ill Patients

Launched by GERALD SUPINSKI · Sep 23, 2014

Keywords

ClinConnect Summary

The basic study design is to:

1. Obtain informed consent from patient or the patients LAR
2. Randomize subjects to treatment with either:

1. Sham therapy, consisting of bilateral placement of Niveus Medical Muscle Stimulation System 110 electrodes for 30 minutes twice daily without activation of the electrical circuitry of the unit, or
2. Active therapy, using the Niveus Medical Muscle Stimulation System 110 electrodes to actively produce a rhythmic quadriceps contraction for 30 minutes twice daily
3. Measure magnetic stimulated quadriceps twitch (QuadTw) strength bilaterally as wel...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Acute respiratory failure requiring mechanical ventilation
• Exclusion Criteria:
• • Attending physician on service determines that patient too unstable to tolerate measurements
• • Patient requires \> 15mcg/min norepinephrine or \> 15mg/kg/min of dopamine.
• • Fraction of inspired oxygen \> 80% or positive end expiratory pressure \> 15 cm H20 requirements.
• • Cardiac pacemaker or implanted defibrillator.
• • Neuromuscular blocking agents delivered within 48 hours of preceding testing.
• • Existing neuromuscular disease.
• • Profound uncorrectable hypokalemia (\< 2.5) OR hypophosphatemia (\< 1.0)
• • Acute lower extremity deep vein thrombosis
• • Pregnancy
• • Prisoner
• • Institutionalized patient
• • If primary attending determines that patient is terminal and will likely have care withdrawn within 7 days
• • Do not resuscitate order
• • Body mass index \> 40
• • Patients requiring mechanical ventilation more than 4 days prior to study entry