Efficacy of AFL-assisted PDT With Short Incubation Time in Actinic Keratosis
Launched by DONG-A UNIVERSITY · Sep 20, 2014
Trial Information
Current as of May 25, 2025
Completed
Keywords
ClinConnect Summary
Photodynamic therapy (PDT) is widely used in the treatment of superficial skin cancer. It has an excellent cosmetic outcome, and it could be considered the first-line therapy for Actinic keratosis (AK). In PDT incubation time is required so that the photosensitizer can be converted to PpIX. The recommended treatment regimen of PDT requires a relatively long incubation time with ALA (4 hours) and MAL (3 hours) before illumination. Theoretically, ablative fractional laser (AFL) pre-treatment may facilitate the penetration and distribution of topically applied drugs, since the ablated laser ho...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • age \>18 years
- • the presence of 2-10 facial AK lesions
- Exclusion Criteria:
- • lactating or pregnant women
- • patients with porphyria
- • a known allergy to any of the constituents of the MAL cream and lidocaine
- • patients with systemic disease
- • history of malignant melanoma
- • tendency for melasma development or keloid formation
- • any AK treatment of the area in the previous 4 weeks
- • any conditions associated with a risk of poor protocol compliance
- • patients on immunosuppressive treatment
About Dong A University
Dong-A University is a prestigious academic institution located in Busan, South Korea, renowned for its commitment to advancing medical research and education. The university actively engages in innovative clinical trials aimed at enhancing healthcare outcomes and addressing pressing medical challenges. With a focus on multidisciplinary collaboration, Dong-A University leverages its state-of-the-art facilities and expert faculty to conduct rigorous research, ensuring adherence to ethical standards and regulatory compliance. The institution is dedicated to translating scientific discoveries into practical applications that benefit patients and the broader community.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Busan, Dong Dae Sin Dong, Seo Gu, Korea, Republic Of
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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