Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis

Launched by NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES (NIAMS) · Oct 4, 2014

Keywords

ClinConnect Summary

This clinical trial is focused on understanding a group of diseases called vasculitis, which cause inflammation in blood vessels and can lead to various health issues. The researchers aim to learn more about the signs, symptoms, and tests that can help identify people with conditions like Takayasu's Arteritis and Giant Cell Arteritis. They want to study how these diseases develop and change over time, including looking at genetic information and conducting imaging tests to see how the blood vessels are affected.

Eligible participants include individuals aged 3 and older who have been diagnosed with vasculitis or are suspected to have it, as well as healthy volunteers. Participants will undergo evaluations by a specialist, provide blood and possibly urine samples, and may have imaging tests to assess their blood vessels. Some may also complete questionnaires. The study may involve a single visit lasting a couple of days, with potential follow-ups every few months. This research hopes to improve our understanding of vasculitis and ultimately help with better diagnosis and treatment for those affected.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • SUBJECTS WITH VASCULITIS
• • Subjects who fulfill modified versions of the 1990 American College of Rheumatology (ACR) Classification Criteria for GPA31 and PAN
• • Subjects who fulfill the 1990 ACR Classification Criteria for EGPA, GCA, and TAK
• • Subjects who fulfill the 2012 Chapel Hill Nomenclature definition for MPA
• • Subjects with other suspected systemic or single-organ vasculitides
• • HEALTHY VOLUNTEERS
• • -Volunteers able to provide consent, or in the case of minors, assent
• EXCLUSION CRITERIA:
• SUBJECTS WITH VASCULITIS:
• • Subjects less than 3 years of age
• • Active malignancy, infection, or any medical condition that in the opinion of the investigator would warrant exclusion
• • Inability to provide consent, or in the case of minors, assent
• • Subjects with bleeding diathesis or on anticoagulant medications (e.g. coumadin, heparin, clopidogrel but not including aspirin or NSAIDs) are excluded from participation in nasal brushing or biopsy studies
• • HEALTHY VOLUNTEERS
• • Volunteers less than 3 years of age
• • Diagnosis of vasculitis or other autoimmune/autoinflamamtory disease, including systemic lupus erythematosus, rheumatoid arthritis, sarcoidosis, mixed connective tissue disease or any overlap autoimmune syndrome
• • Active malignancy, infection, or any medical condition that in the opinion of the investigator would warrant exclusion
• • Pregnant (by history of last menstrual period) or breast feeding subjects
• • Subjects with bleeding diathesis or taking anticoagulant medications (eg coumadin, heparin, clopidogrel but not including aspirin or NSAIDs) are excluded from participating in nasal brushing studies