Effect of a Butyrate Enema on the Systemic Concentration of Short Chain Fatty Acids
Launched by MAASTRICHT UNIVERSITY MEDICAL CENTER · Oct 21, 2014
Trial Information
Current as of July 21, 2025
Completed
Keywords
ClinConnect Summary
Patients undergoing upper abdominal surgery are included. During surgery they receive a butyrate enema or placebo enema. Before and after rectal administration, plasma samples are taken from several veins and arteries to analyse SCFA concentrations and fluxes from portal drained viscera, liver and the splanchnic area.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • patients undergoing open liver resection or pancreaticoduodenectomy
- Exclusion Criteria:
- • known parenchymal liver disease
- • presence of ileostomy or colostomy
- • patients with inflammatory bowel disease
- • antibiotics, prebiotics or probiotics 2 months prior to surgery
About Maastricht University Medical Center
Maastricht University Medical Center (MUMC+) is a leading academic medical center in the Netherlands, renowned for its commitment to advancing healthcare through innovative research and education. As a prominent sponsor of clinical trials, MUMC+ integrates cutting-edge scientific inquiry with clinical practice, focusing on a wide range of medical disciplines. The center emphasizes collaboration among multidisciplinary teams, fostering an environment that promotes excellence in patient care and the translation of research findings into clinical applications. MUMC+ is dedicated to improving health outcomes and enhancing quality of life through rigorous clinical investigations and the development of novel therapeutic strategies.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Maastricht, , Netherlands
Patients applied
Trial Officials
CHC Dejong, MD, PhD
Principal Investigator
Maastricht University Medical Center
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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