Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults

Launched by CHILDREN'S HOSPITAL MEDICAL CENTER, CINCINNATI · Oct 20, 2014

Keywords

ClinConnect Summary

This clinical trial is looking at a special type of MRI using a gas called hyperpolarized xenon (HP 129Xe) to see how well the lungs are working in both children and adults. The researchers want to find out how effective this imaging technique is for assessing lung function, especially in people who have breathing problems due to various lung diseases.

To participate, you need to be at least 6 years old and be able to hold your breath for up to 16 seconds. However, if you have certain health issues, like a history of heart defects, recent respiratory infections, or severe asthma, you may not be eligible. If you join the study, you will undergo an MRI scan that uses this special gas, which is designed to provide better pictures of your lungs. The trial is currently recruiting participants of all genders, and it’s a great opportunity to help advance research in lung health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Ages 6 and up
• • Participant must be able to hold breath for up to 16 seconds
• Exclusion Criteria:
• • History of heart defect
• • Pregnancy or positive pregnancy test
• • History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month
• • Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week
• • Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula
• • Participant is claustrophobic and unable to tolerate the imaging.
• • Standard MRI exclusions (metal, implants)