Medico-GDM Trial - Metformine to Prevent Gestational Diabetes Mellitus

Launched by MAASSTAD HOSPITAL · Oct 24, 2014

Keywords

ClinConnect Summary

Rationale: GDM is a frequent pregnancy complication1 and associated with complications for mother and child.2 At present, the drug of choice for treatment of GDM is Insulin.3 In the last years several studies documented the use of oral blood glucose lowering medication in GDM. Metformin is an accepted alternative for insulin, with comparable glycemic control and neonatal outcomes.4 In studies with women with polycystic ovarian syndrome (PCOS) who received Metformin during pregnancy, the incidence of GDM is less compared to pregnant women with PCOS without Metformin. These studies were howev...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• a subject must meet all of the following criteria:
• • high risk (according to ductch national criteria) for gestational diabetes
• • aged between 18 and 40 years
• • gestational age between 8 and 12 weeks
• • and able to communicate and read in Dutch.
• Exclusion Criteria:
• A potential subject who meets any of the following criteria will be excluded from participation in this study:
• • no singleton pregnancy judged by ultrasonography
• • diagnosis of diabetes mellitus before the current pregnancy-
• • high fasting glucose at first trimester (\> 5.3 mmol/l)
• • cardiac insufficiency-\\
• • renal insufficiency (MDRD \< 60)
• • liver disease
• • use of medication other than Paracetamol or vitamins and incompetent women.