Activated MMP-8 as Diagnostic Test for Periodontitis
Launched by GOETHE UNIVERSITY · Oct 29, 2014
Trial Information
Current as of May 04, 2025
Completed
Keywords
ClinConnect Summary
.The hypotheses behind this study were:
- The aMMP-8 test discriminates between individuals with and without untreated generalized chronic periodontitis
Thus, sensitivity and specificity of a chair-side test for activated matrix metalloproteinase-8 to distinguish between individuals with and without untreated chronic periodontitis as well as between patients with generalized moderate and generalized severe ChP was evaluated.
Patients
A commercially available chair side test to detect increased levels of activated matrix metalloproteinase-8 was used at Dr. Matthias Mayer's dental office ...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • At least18 years of age
- • Clinical diagnosis of generalized moderate or generalized severe ChP
- • At least 5 teeth present per quadrant
- • After application to the ethics committee: written informed consent
- Exclusion Criteria:
- • Requirement of systemic antibiotics for measures that may cause transitory bacteraemia (e.g. pocket probing)
- • Nonsurgical or surgical periodontal treatment within the last 12 months prior to PerioMarker® test
- • Systemic or topical subgingival antibiotics within the last 6 months prior to PerioMarker® test
- • Anti-inflammatory medication (e.g. non-steroidal anti-inflammatory drugs) during the last 3 months prior to PerioMarker® test
About Goethe University
Goethe University, located in Frankfurt, Germany, is a prestigious academic institution renowned for its commitment to research excellence and innovation in various fields, including medicine and health sciences. As a clinical trial sponsor, Goethe University leverages its robust interdisciplinary resources and expertise to advance medical research and improve patient outcomes. The university fosters collaboration among faculty, researchers, and healthcare professionals to design and conduct rigorous clinical trials, ensuring adherence to ethical standards and regulatory requirements. Through its dedication to scientific inquiry and public health, Goethe University plays a pivotal role in translating research findings into practical applications that benefit society.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Trial Officials
Peter Eickholz, Dr.
Study Chair
Johann Wolfgang Goethe-Universität
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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