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Search / Trial NCT02288923

Trial to Compare Femoral Nerve Block With Local Anaesthetic Injection for Post-operative Pain After Knee Replacement.

Launched by ROYAL DEVON AND EXETER NHS FOUNDATION TRUST · Nov 7, 2014

Trial Information

Current as of July 22, 2025

Completed

Keywords

Total Knee Arthroplasty Femoral Nerve Block Local Infiltration Analgesia

ClinConnect Summary

Knee pain and stiffness is a common problem which can sometimes be improved by inserting a replacement knee joint. An anaesthetist is a doctor who specialises in looking after patients undergoing surgery, and there are a variety of different anaesthetics which can be used for knee replacement surgery. These include general anaesthesia (going to sleep), and spinal or epidural anaesthesia (where pain killers are injected into the back, resulting in temporarily numb legs). Pain killers can also be injected around the nerves which supply the leg, or around the site of the operation itself, comb...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • All adult patients presenting for primary knee arthroplasty under the care of the Exeter Knee Unit Consultants Messrs Toms, Eyres, Cox, Mandalia, Schrantz.
  • Exclusion Criteria:
  • 1. Total knee arthroplasty for trauma
  • 2. Unicompartmental surgery
  • 3. Bilateral surgery
  • 4. Contra indication to spinal anaesthesia or peripheral nerve blocks (anticoagulation, hydrocephalus, raised intracranial pressure, peripheral neuropathy)
  • 5. Allergy to local anaesthetics or morphine
  • 6. Chronic pain:
  • Under active follow up by chronic pain team
  • Chronic strong opiate use (morphine, oxycodone, buprenorphine, pethidine, methadone). Codeine, dihydrocodeine and tramadol are not included
  • Other chronic pain medications (including gabapentin, pregabalin or amitriptyline)
  • 7. Unable to adequately understand verbal explanations or written information given in English, or patients with special communication needs -

About Royal Devon And Exeter Nhs Foundation Trust

The Royal Devon and Exeter NHS Foundation Trust is a leading healthcare organization dedicated to delivering high-quality patient care and advancing medical research. Located in Exeter, the Trust is committed to innovation and excellence in clinical trials, facilitating studies that aim to improve health outcomes and enhance treatment options across various medical disciplines. With a strong emphasis on collaboration, the Trust partners with researchers, healthcare professionals, and patients to foster a research environment that prioritizes safety, ethical standards, and scientific integrity. Through its robust infrastructure and expertise, the Royal Devon and Exeter NHS Foundation Trust plays a vital role in the advancement of evidence-based medicine and the translation of research findings into clinical practice.

Locations

Exeter, Devon, United Kingdom

Patients applied

0 patients applied

Trial Officials

Fiona Martin, MBCHB

Principal Investigator

Royal Devon and Exeter NHS Foundation Trust

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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