Analysis of Prognostic Cell Signaling Factors in Adolescent Idiopathic Scoliosis

Launched by UNIVERSITY OF COLORADO, DENVER · Dec 9, 2014

Keywords

ClinConnect Summary

This clinical trial is looking to find out more about adolescent idiopathic scoliosis (AIS), a condition where the spine curves abnormally in young people, especially girls aged 10 to 13 years. The main goal is to identify specific genetic markers that might help predict which children with mild spine curvature are likely to experience worsening of their condition. Currently, doctors can’t always tell which patients will need surgery in the future. By finding these markers, researchers hope to develop a simple test that can help identify children at risk and determine who might benefit from early treatment.

To participate in this study, girls aged 10-13 with a mild to moderate spinal curve (measured as a Cobb angle between 15-30 degrees) may be eligible. However, those with other types of scoliosis, past spine surgeries, or certain health conditions like diabetes or cancer won't be included. If selected, participants will undergo tests to look at these genetic markers, which could lead to better ways to manage and treat scoliosis in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Females aged 10-13 years
• • Diagnosed with mild-moderate spine deformity (Cobb angle 15-30 degrees)
• Exclusion Criteria:
• • Patients with scoliosis other than idiopathic
• • Trauma
• • Inflammatory disease
• • Malignancies
• • Diabetes
• • History of previous spine surgery