Recording High Frequency Oscillations in Patients With Tumors and Epilepsy

Launched by UNIVERSITY OF ZURICH · Dec 18, 2014

Keywords

ClinConnect Summary

This study is watching a specific Brain signal called high-frequency oscillations (HFOs) that may come from seizure-causing areas in the brain, as well as signals that happen during normal brain activity. The researchers want to see if they can reliably record these HFOs in people who are being considered for brain surgery or who have brain tumors that have caused seizures, both during surgery and in the time around surgery. The goal is to understand whether these signals can help identify the parts of the brain involved in seizures and normal brain function.

Who can participate? Adults aged 18 to 99 who have epilepsy and are planning a surgical treatment, or who have a brain tumor that has caused seizures or not. The study plans to enroll about 120 people and is observational (no experimental treatment is given). Participants will do simple cognitive tasks (like watching a video or memory tasks) and may have brain recordings as part of their usual clinical care. Key eligibility includes giving informed consent and meeting criteria set by the study, with standard exclusions such as contraindications to participation, inability to comply, substance issues, or recent enrollment in another trial. The study is led by the University of Zurich, and the main outcome is how often HFOs occur within the first week of recording.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients intend to be treated at the Klinik für Neurochirurgie
• • Patients fall into one of the patient groups: (1) Patients with symptomatic epilepsy with focal and/or secondary generalized seizures resistant to medication where a neurosurgical resection is considered as an intervention of epilepsy surgery. (2)Patients where a tumor is planned to be resected that has caused preoperative seizures. (3) Patients where a tumor is planned to be resected that has not caused preoperative seizures.
• • Male and Female subjects 18 years to 99 years of age
• • Written informed consent after participants' information
• Exclusion Criteria:
• • contraindications on ethical grounds
• • known or suspected non-compliance, drug or alcohol abuse,
• • enrolment into a clinical trial within last 4 weeks