Phenotype, Genotype & Biomarkers in ALS and Related Disorders

Launched by UNIVERSITY OF MIAMI · Dec 24, 2014

Keywords

ClinConnect Summary

This study will recruit patients with ALS, ALS-FTD, PLS, HSP, and PMA, with a focus on incident cases. Patients with both familial and sporadic forms of these diseases will be enrolled and followed longitudinally using a standardized set of evaluations. Biological samples (blood, urine, CSF) will be collected from all study participants, and will be used for biomarker discovery and validation. Family members of affected individuals may also be enrolled and asked to contribute DNA and biological samples to aid genetic and biomarker discovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Member of at least one of the following categories:
• • 1. Individuals with a clinical diagnosis of ALS or a related disorder, including FTD, HSP, PLS, PMA and MSP (sporadic or familial).
• • 2. Family member of an enrolled affected individual.
• • Able and willing to comply with relevant procedures.
• Exclusion Criteria:
• • Affected with end or late stage disease.
• • A condition or situation which, in the PI's opinion, could confound the study finding or may interfere significantly with the individual's participation and compliance with the study protocol. This includes (but is not limited to) neurological, psychological and/or medical conditions.