Effect of Local Endometrial Injury on Pregnancy Outcomes During Ovulation Induction Cycles

Launched by AL HAYAT NATIONAL HOSPITAL · Jan 20, 2015

Keywords

ClinConnect Summary

Patients will be randomized using a list of computer generated random sample into two groups:

Group 1: Couples who will undergo endometrial sampling in the luteal phase of the cycle preceding ovulation induction by clomiphene citrate.

Group 2: Couples who will undergo ovulation induction with clomiphene citrate. The drug chosen for ovulation induction in both groups will be clomephine citrate.

Timing and technique of endometrial sampling:

Timing: from day 15 to day 24 of the cycle preceding ovulation induction cycle. Technique: this will be done using the pipelle method (Williams et al....

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Male partner should have a normal semen count and motility according to world health organization criteria (Murray et al., 2012).
• • 2. Primary, secondary or unexplained infertility for at least one year.
• • 3. Failure to conceive with clomiphene citrate in spite of good follicular response for at least 3 cycles.
• • 4. Age varies from 20-35 years with at least one year of infertility.
• • 5. Body mass index between 19-30 kg/m2.
• • 6. Day 2 serum FSH\< 12 IU/ml.
• • 7. Normal uterine cavity on hystrosalpingography.
• • 8. At least one patent tube of normal appearance on HSG.
• • 9. No previous attempts of intrauterine insemination (IUI) or in vitro fertilization (IVF).
• Exclusion Criteria:
• • 1. Infertility due to tubal factor or male factor.
• • 2. Intrauterine organic pathology (myoma, polyp, adhesions) by hystrosalpingogram or diagnostic hysteroscope.
• • 3. Hypogonadotrophic hypogonadism.