Efficacy of HIPEC in the Treatment of Locally Advanced Gastric Cancer After radIcal Gastrectomy With D2

Launched by AFFILIATED CANCER HOSPITAL & INSTITUTE OF GUANGZHOU MEDICAL UNIVERSITY · Feb 4, 2015

Keywords

ClinConnect Summary

Gastric cancer (GC) is the fourth most common cancer, and the second leading cause of cancer-related death worldwide. Advances in diagnostic and therapeutic approaches have achieved long-term survival for early GC. However, receiving perioperative/postoperative systemic chemotherapy and gastrectomy with D1-D2 lymph node dissection, 5-year survival rates of advanced gastric cancer remain under 30%. 40-60% of recurrences are peritoneal and/or locoregional. hyperthermic intraperitoneal chemotherapy (HIPEC) technique is increasingly used in the curative treatment of primary and digestive perito...

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Eligibility criteria

• Inclusion Criteria:
• • 18 \< age ≤ 70 years old
• • Male or Non pregnant female
• • The Eastern Cooperative Oncology Group (ECOG) status 0-1
• • T3 or T4 gastric adenocarcinoma (visual determination according to AJCC 2010 7th edition)
• • No distance metastasis, eligible for D2 lymphadenectomy
• • Have not received cytotoxic chemotherapy, radiotherapy or immunotherapy
• • White blood cells \> 4,000/mm3
• • neutrophils ≥ 1,500/mm3
• • platelets ≥ 100,000/mm3
• • hemoglobin\>9g/l
• • Alanine transaminase (ALT) and aspartate aminotransferase (AST) \< or = 2.5 times upper limit of nominal (ULN)
• • total bilirubin (TBIL) \< 1.5 times ULN
• • serum creatinine \< 1 times ULN
• • Having given written informed consent prior to any procedure related to the study
• Exclusion Criteria:
• • Have other cancer within 5 years
• • Existence of distance metastasis during surgey (M1)
• • Prior malignant tumors with detectable signs of recurrence or distant metastasis
• • Poorly controlled disease e.g. atrial fibrillation, stenocardia, cardiac insufficiency, persistent hypertension despite medicinal treatment, ejection fraction\<50%
• • Epileptic seizures patients need medicine control
• • Uncontroled mental disease or mental disorder
• • Drug abuse or psychological or social factors affect the judgment of results
• • Contraindication to any therapy contained in this regimen specific to the study
• • Receiving other chemotherapy, radiotherapy or immunotherapy
• • Without given written informed consent