ART-2 Pilot - Driving Pressure Limited Ventilation for Patients With ARDS
Launched by HOSPITAL DO CORACAO · Feb 17, 2015
Trial Information
Current as of September 03, 2025
Completed
Keywords
ClinConnect Summary
Mechanical ventilation has the potential to produce or worsen alveolar injury. Driving pressure is the difference between plateau pressure and PEEP. Evidence from observational studies suggests that elevated driving pressure is the main independent determinant of ventilator-induced lung injury, however clinical trials are needed to establish whether targeting low driving pressures can improve clinical outcomes in patients with acute respiratory distress syndrome (ARDS). Thus, ART2pilot is a multicenter randomized controlled trial to assess the feasibility of a driving pressure limited mecha...
Gender
ALL
Eligibility criteria
- Inclusion criteria:
- • Patients on invasive mechanical ventilation with diagnosis of ARDS of less than 72 hours duration.
- Exclusion criteria:
- • Less than 18 years old.
- • Presence of any contraindication to hypercapnia as suspected or confirmed intracranial hypertension or recent (\<7 days) acute coronary syndrome.
- • Patients in which a high probability of death within 24 hours is anticipated.
- • Patients under exclusive palliative care.
About Hospital Do Coracao
Hospital do Coração is a leading medical institution specializing in cardiovascular health and research. Committed to advancing heart care through innovative clinical trials, the hospital integrates cutting-edge technology and evidence-based practices to enhance patient outcomes. With a team of experienced cardiologists, researchers, and healthcare professionals, Hospital do Coração aims to contribute significantly to the global understanding of cardiovascular diseases while providing high-quality care to its patients. The institution fosters a collaborative environment that encourages the development of new therapies and treatments, ultimately striving to improve the quality of life for individuals affected by heart conditions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Trial Officials
Alexandre B Cavalcanti, MD, PhD
Study Chair
Hospital do Coracao (Heart Hospital)
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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