Rosuvastatin Gel With 1:1 Mixture of Platelet-rich Fibrin and Bone Graft in Mandibular Degree II Furcation Defects

Launched by GOVERNMENT DENTAL COLLEGE AND RESEARCH INSTITUTE, BANGALORE · Feb 17, 2015

Keywords

ClinConnect Summary

ABSTRACT Background: A wide range of regenerative materials have been tried in the treatment of furcation defects. Rosuvastatin (RSV) is a new synthetic, second-generation, sulfur-containing, hydrophilic statin, that stimulate bone formation in critical-size cortical bone defects adjacent to titanium implants, when administered locally in bone. Platelet-rich fibrin (PRF) is a platelet concentrate with sustained release of various growth factors, having regenerative potential to treat periodontal defects. Porous hydroxyapatite (HA) bone grafting material has clinically satisfactory response,...

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Eligibility criteria

• Inclusion Criteria:
• • 1. the presence of buccal Class II furcation defects in endodontically vital, asymptomatic mandibular first and second molars with a radiolucency in the furcation area on an intraoral periapical radiograph with PD ± 5mm and horizontal PD ± 3mm after Phase I therapy (SRP)
• • 2. no history of antibiotic or periodontal therapy in the preceding 6 months.
• Exclusion Criteria:
• • 1. systemic illness known to affect the outcomes of periodontal therapy, such as diabetes mellitus, cardiac diseases, insufficient platelet count (\<200,000/mm3), or immunocompromised (e.g., HIV individuals) patients taking medications, such as corticosteroids or calcium channel blockers, which are known to interfere with periodontal wound healing
• • 2. individuals known or suspected allergy to the RSV group or allergic to medications
• • 3. systemic statin therapy
• • 4. pregnant or lactating women
• • 5. patients using tobacco in any form
• • 6. individuals with unacceptable oral hygiene (plaque index \>1.5). In addition, teeth with interproximal intrabony defects, gingival recession, endodontic (pulpal) involvement, or mobility of tooth ≥ Grade II were also excluded.