Effect of Inhaled Mometasone/Formoterol Versus Inhaled Fluticasone/Salmeterol in Asthma Patients

Launched by MAHIDOL UNIVERSITY · Apr 8, 2015

Keywords

ClinConnect Summary

Peripheral airway dysfunction is associated with poor asthma outcome including asthma exacerbation and more symptoms. The peripheral or small airway is anatomically defined by airways with 2 mm diameter or less. Several techniques have been used for evaluating peripheral airways such as spirometry, body plethysmography, impulse oscillometry and imaging studies. Since inhaled corticosteroid is corner stone for treatment of asthma, the addition of long acting beta agonist is indicated in severe asthma with poorly controlled disease despite of high dose inhaled corticosteroid.

The inhaled cor...

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Eligibility criteria

• Inclusion Criteria:
• • 1. Newly diagnosed asthma according to Global Initiative for Asthma (GINA) guideline 2014 without previous treatment of inhaled corticosteroid and long acting beta agonists
• • 2. Patients with asthma symptoms of most days or wake up due to asthma one time per week or more
• • 3. Patients with the presence of any risk factors of asthma according to Global Initiative for Asthma (GINA) guideline 2014
• • 4. Patients with severe uncontrolled asthma
• • 5. Patients with previous asthma exacerbation
• • 6. Patients give consent form
• Exclusion Criteria:
• • 1. Patients with contra-indication for performing spirometry according to American Thoracic Society (ATS) and European Respiratory Society (ERS) statement of standardization for spirometry
• • 2. Patients refuse to participate study -