MRI Technical Development and Applications in Kidney Disease

Launched by UNIVERSITY OF MINNESOTA · Apr 17, 2015

Keywords

ClinConnect Summary

This clinical trial is exploring how advanced MRI (Magnetic Resonance Imaging) techniques can help us better understand and manage kidney diseases, including chronic kidney disease (CKD) and conditions related to kidney transplants and dialysis. The researchers aim to develop new MRI methods to take clearer images of the kidneys and assess their function. They also want to see how kidney issues might affect brain health, particularly focusing on conditions like memory problems and strokes that can occur when the kidneys don’t work well.

To participate in the trial, you should be between 45 and 74 years old and able to communicate in English. You’ll need to be healthy enough to complete some cognitive tests, which are designed to measure your thinking skills. If you have any significant health issues, such as severe breathing problems or are currently receiving dialysis or have had a kidney transplant, you may not be eligible. Participants will undergo MRI scans and cognitive testing, and this could help improve future treatments for kidney disease and its effects on the brain.

Gender

ALL

Eligibility criteria

• • For Specific Aim 1: MRI Technical Development Studies
• Inclusion Criteria:
• • 1. Healthy Volunteer
• Exclusion Criteria:
• • 1. Ferromagnetic implants
• • 2. Any foreign metal objects in the body
• • 3. History of shrapnel or shot gun injury
• • 4. Cardiac pacemakers
• • 5. Defibrillator
• • 6. Neuronal stimulator
• • 7. Magnetic aneurysm clip
• • 8. Large tattoos on the abdomen or the brain and neck
• • 9. Hip replacement
• • 10. Too large to fit in the magnet (body mass index \>= 40, approx.)
• • 11. Severe claustrophobia
• • 12. Women with pregnancy
• • For Specific Aim 2: Pilot Studies with Patients
• • Studies for CKD
• • Inclusion
• • 1. English- speaking as primary language.
• • 2. Age 45 years and older
• • 3. Able to complete an approximately 90 minute cognitive testing battery.
• • 4. Able to sign the informed consent, or allow a caregiver, relative, surrogate, or witness to sign the informed consent if participant is unable to do so.
• • 5. GFR \< 90 ml/min/1.73m2
• • Exclusion
• • 1. Acute psychiatric illness that would impede cognitive testing
• • 2. Active chemical dependence, such as alcohol, narcotics or other drugs
• • 3. Legally blind or unable to complete cognitive tests due to visual loss or deafness
• • 4. Dialysis dependent or renal transplant recipient at time of screening or baseline
• • 5. Chronic obstructive pulmonary disease
• • 6. Severe CI unable to complete the Modified Mini-Mental State Examination \[3MSE\]
• • Studies for Renal Transplantation
• • Inclusion
• • 1. Able to sign the informed consent, or allow a caregiver, relative, surrogate, or witness to sign the informed consent if participant is unable to do so.
• • 2. Age 45 years and older
• • Exclusion
• • 1. Not on dialysis due to allograft failure
• • 2. Chronic obstructive pulmonary disease