Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway

Launched by KU LEUVEN · Apr 21, 2015

Keywords

ClinConnect Summary

This clinical trial is looking at a medication called prucalopride to see if it can help reduce inflammation and speed up recovery after surgery in patients who have part or all of their pancreas removed due to a tumor. The researchers believe that prucalopride can have a similar effect to a treatment called vagus nerve stimulation, which involves sending electrical signals to help manage inflammation in the body.

To participate in this study, patients should be between the ages of 65 and 74 and must be scheduled for pancreatic surgery. However, individuals with certain conditions, such as chronic pancreatitis or poorly controlled diabetes, will not be eligible. If you join the trial, you can expect to receive prucalopride and be closely monitored to see how it affects your recovery after surgery. The trial is currently recruiting participants, and it's an opportunity to possibly contribute to new treatments that can help improve recovery for others in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • patients undergoing partial or full resection of the pancreas due to a benign or malignant tumor
• Exclusion Criteria:
• • adjuvant radiotherapy
• • evident intra-abdominal inflammation (diagnosed by imaging and/or laboratory results, including an abscess or cholecystitis)
• • chronic pancreatitis
• • pancreatic polypeptide producing endocrine tumor
• • American Society of Anesthesiologists physical-health status classification (ASA-PS)\>3
• • Poorly regulated diabetes (\>200 mg/dl (=11 mmol/l))