Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy

Launched by POST GRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH, CHANDIGARH · May 13, 2015

Keywords

ClinConnect Summary

This is a prospective randomized study to assess the efficacy and safety of a single dose of cefazolin 2g IV for the prophylaxis of surgical site and pleural space infections during medical thoracoscopy.

Consecutive patients who are planned to undergo a medical thoracoscopy (rigid or semirigid) will be enrolled in the study if they satisfy the inclusion and exclusion criteria. One hundred patients will be randomized in 1:1 ratio to receive either of the following: (a) A single dose of intravenous cefazolin 2 gms dissolved in 100 mL of normal saline administered over 10 minutes, between 15 ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥12 years
• • 2. Medical thoracoscopy being performed for a pleural effusion for any of the three indications: diagnosis, pleurodesis, or adhesiolysis
• Exclusion Criteria:
• • 1. Age ≥80 years
• • 2. Pao2/FIO2\< 300;
• • 3. Hemodynamic instability
• • 4. Myocardial infarction or unstable angina in the last 6 wk
• • 5. Lack of pleural space due to adhesions
• • 6. Uncorrected coagulopathy
• • 7. Failure to provide informed consent
• • 8. Patients already taking any antibiotic due to any reason