Antibiotic Dosing in Pediatric Intensive Care

Launched by UNIVERSITY HOSPITAL, GHENT · May 26, 2015

Keywords

ClinConnect Summary

This clinical trial is studying how different antibiotics work in critically ill children, including neonates, infants, and older kids. Specifically, the researchers want to understand how well the body absorbs and processes antibiotics like piperacillin-tazobactam, amoxicillin-clavulanate, vancomycin, and others when given to patients in the pediatric intensive care unit (PICU). The goal is to improve treatment by finding the best dosing for these medications in young patients who are very sick.

To participate in this study, children aged between 1 month and 15 years who are being treated with these antibiotics in the PICU may be eligible. They should have a way for doctors to take blood samples, like an intravenous line, and must not have certain allergies or medical conditions that could complicate the study. Participants can expect to have some blood tests done to help researchers learn how the antibiotics are working in their bodies. This research is important because better understanding antibiotic dosing can lead to more effective treatments for critically ill children.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • patients admitted to the pediatric intensive care unit
• • patient age/weight : 1,8 kg-15 years
• • patient receiving antibiotic treatment (piperacillin-tazobactam, amoxicillin-clavulanate, vancomycin, teicoplanin, meropenem, ciprofloxacin, amikacin) via intermittent infusion regimen or continuous infusion according to institutional treatment guidelines
• • intra-arterial or intravenous access other than the drug infusion line available for blood sampling (arterial line is preferred)
• Exclusion Criteria:
• • no catheter in place for blood sampling
• • absence of parental/patient consent
• • known hypersensitivity to beta-lactam antibiotics, glycopeptides, fluoroquinolones, aminoglycosides
• • extracorporeal circuit (haemodialysis, ECMO, peritoneal dialysis )