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Search / Trial NCT02474160

Collection and Storage of Tissue and Blood Samples From Patients With Cancer

Launched by NATIONAL CANCER INSTITUTE LAO · Jun 15, 2015

Trial Information

Current as of July 23, 2025

Recruiting

Keywords

ClinConnect Summary

This clinical trial is focused on collecting and storing tissue and blood samples from people diagnosed with cancer. The goal is to use these samples to help scientists better understand cancer and to test new treatments. By studying these samples in a lab, researchers hope to create improved models that can lead to better cancer therapies in the future.

To participate, you need to be at least 18 years old and have a confirmed diagnosis of cancer, or be under evaluation for a possible cancer diagnosis. This includes patients with various forms of cancer, whether it's newly diagnosed, recurrent, or currently being treated. If you choose to participate, you'll be asked to provide blood and tissue samples, which will be collected at specific times related to your treatment. It's important to know that your participation will help advance cancer research, and you’ll need to sign a consent form agreeing to the use of your samples for this purpose.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Patients older than 2 months of age who are being evaluated, treated, or enrolled in a clinical trial for cancer at participating sites
  • Patients with a histologically or cytologically confirmed diagnosis of cancer
  • Patients without histologically or cytologically confirmed diagnosis of cancer, but for whom approval has been requested and received from the coordinating site study coordinator
  • * Requests for coordinating site approval should only be made if the patient's existing work-up at the time of the request demonstrates a combination of two or more of the following indicating the greater likelihood of a cancerous process in the assessment of the treating physician:
  • Radiographic imaging (computed tomography \[CT\], magnetic resonance imaging \[MRI\], etc.)
  • Elevated tumor markers
  • Clinical symptoms
  • Documented risk factors, known genetic changes (mutation, deletion, fusion, etc.), and/or known familial cancer history or syndrome
  • Complete blood count (CBC) w/differential indicative of a probable hematologic malignancy
  • If the patient will be undergoing surgical resection at a later time and will be accessible to approach for study participation at that time, resected material following cancer diagnosis confirmation is preferred
  • Important: Additional medical, genetic and/or demographic work-up should not be obtained solely for determination of eligibility for protocol 9846 by these criteria. Once available, final histology must be confirmed to the coordinating site detailing the cancer diagnosis for patients enrolled based on the above criteria
  • Patients with a newly diagnosed primary and/or metastatic solid tumor or hematologic malignancy for which they have not yet received treatment
  • * Patients with a solid tumor or hematologic malignancy that is recurrent, newly metastasized, or progressing while on treatment indicated by:
  • Radiographic evidence of tumor growth, re-growth, and/or new metastases, OR
  • Documentation by the treating physician of clinical disease progression, OR
  • CBC w/differential and/or flow cytometry for hematologic malignancies
  • Patients currently undergoing treatment (adjuvant, neoadjuvant, etc.)
  • Specimen collection should occur as distant in time from the most recent drug administration as possible (e.g., after completion of a treatment cycle and immediately prior to initiation of the next cycle)
  • Specimens should not be collected from patients between doses within a single treatment cycle
  • Confirmation of viable residual malignancy and/or \< 90% tumor necrosis, fibrosis, or hemorrhage must be confirmed to the National Cancer Institute (NCI) coordinating site, as indicated in the final post-operative/post-procedure pathology and/or flow cytometry report
  • Patients with ongoing partial response (PR) or stable disease (SD) are eligible
  • Confirmation of viable malignancy and/or \< 90% tumor necrosis, fibrosis, or hemorrhage must be confirmed to the NCI coordinating site, as indicated in the final post-operative/post-procedure pathology and/or flow cytometry report
  • Ability to understand and willingness to sign a written informed consent document indicating their willingness to have their tissue or biologic fluid specimens used for research as outlined in this protocol
  • For pediatric patients, ability and willingness to assent to participation, using an explanation that is understandable/age appropriate, as well as receiving parental permission. Signature requirements for pediatric patients can be adjusted based on local guidelines
  • Exclusion Criteria:
  • Patients with cancer-like syndromes and/or blood disorders such as systemic mastocytosis, Langerhans cell histiocytosis, chronic eosinophilic leukemia/hypereosinophilic syndrome, lymphomatoid granulomatosis, or monoclonal gammopathy of undetermined significance (MGUS)
  • Patients with invasive fungal infections
  • Patients with active and/or uncontrolled bacterial, fungal, or viral infections or who are still recovering from an infection
  • Actively febrile patients with uncertain etiology of febrile episode
  • All antibiotics prescribed for the treatment of a bacterial infection should be completed at least 1 week (7 days) prior to collection
  • Patients with a hematologic malignancy who are treated with an antibiotic, anti-fungal, and/or anti-viral medication for an active infection who then remain on the treatment for prophylaxis following resolution of the infection as assessed by the treating physician are not excluded
  • No recurrence of fever or other symptoms related to infection for at least 1 week (7 days) following completion of antibiotics
  • Patients receiving antibiotics, antifungals, and/or antivirals for prophylaxis are permissible
  • Antibiotics being administered topically at a location distant from the planned tissue collection site or eye drops for a localized infection are permissible
  • Patients with human immunodeficiency virus (HIV), active or chronic hepatitis (i.e., quantifiable hepatitis B virus \[HBV\]-deoxyribonucleic acid \[DNA\] and/or positive hepatitis B surface antigen \[HbsAg\], quantifiable hepatitis C virus \[HCV\]-ribonucleic acid \[RNA\]) or known history of HCV, HBV, or HIV; testing for HBV, HCV, HIV or other infections for eligibility will be performed only if clinically indicated
  • Patients with hepatitis A as indicated by anti-hepatitis A virus (HAV) IgM reactivity
  • Patients that are anti-HAV IgG reactive only are eligible
  • Specimen collections from patients with benign tumors including but not limited to desmoid tumors, carcinoma in situ, or ongoing evidence of complete disease response (CR)

About National Cancer Institute Lao

The National Cancer Institute Lao (NCIL) is a leading research organization dedicated to advancing cancer prevention, treatment, and care within Lao PDR. As a sponsor of clinical trials, NCIL focuses on conducting innovative research that addresses the unique cancer-related challenges faced by the population. With a commitment to collaboration, the institute works closely with international partners, healthcare providers, and researchers to enhance cancer research capabilities and improve patient outcomes. Through its rigorous clinical trials, NCIL aims to contribute valuable insights to the global cancer research community and promote evidence-based practices in oncology.

Locations

New Haven, Connecticut, United States

Durham, North Carolina, United States

Saint Louis, Missouri, United States

Peoria, Illinois, United States

Boston, Massachusetts, United States

Wichita, Kansas, United States

Duarte, California, United States

La Crosse, Wisconsin, United States

Chanute, Kansas, United States

Dodge City, Kansas, United States

Newton, Kansas, United States

Wellington, Kansas, United States

Winfield, Kansas, United States

Kalamazoo, Michigan, United States

Traverse City, Michigan, United States

Houston, Texas, United States

Mount Vernon, Illinois, United States

Salina, Kansas, United States

Wichita, Kansas, United States

Ann Arbor, Michigan, United States

Effingham, Illinois, United States

Fort Scott, Kansas, United States

Independence, Kansas, United States

Lawrence, Kansas, United States

Saint Joseph, Missouri, United States

Springfield, Illinois, United States

Springfield, Illinois, United States

Boston, Massachusetts, United States

Birmingham, Alabama, United States

Los Angeles, California, United States

Aurora, Colorado, United States

Baltimore, Maryland, United States

Saint Louis, Missouri, United States

Bronx, New York, United States

New York, New York, United States

Chapel Hill, North Carolina, United States

Seattle, Washington, United States

Newark, Delaware, United States

Bronx, New York, United States

Auburn, Washington, United States

Puyallup, Washington, United States

Cape Girardeau, Missouri, United States

Saint Louis, Missouri, United States

Memphis, Tennessee, United States

Augusta, Georgia, United States

Rochester, Minnesota, United States

Saint Louis, Missouri, United States

Bronx, New York, United States

Marshfield, Wisconsin, United States

Decatur, Illinois, United States

Bloomington, Illinois, United States

Ottawa, Illinois, United States

Peoria, Illinois, United States

Peoria, Illinois, United States

El Dorado, Kansas, United States

Kingman, Kansas, United States

Parsons, Kansas, United States

Pratt, Kansas, United States

Wichita, Kansas, United States

Wichita, Kansas, United States

Galesburg, Illinois, United States

Reed City, Michigan, United States

Cape Girardeau, Missouri, United States

Peru, Illinois, United States

Kalamazoo, Michigan, United States

Galesburg, Illinois, United States

Pekin, Illinois, United States

Wichita, Kansas, United States

Battle Creek, Michigan, United States

Grand Rapids, Michigan, United States

Grand Rapids, Michigan, United States

Muskegon, Michigan, United States

Saint Joseph, Michigan, United States

Joplin, Missouri, United States

Springfield, Missouri, United States

Springfield, Missouri, United States

Eau Claire, Wisconsin, United States

Minocqua, Wisconsin, United States

Rice Lake, Wisconsin, United States

Stevens Point, Wisconsin, United States

Wausau, Wisconsin, United States

Weston, Wisconsin, United States

Chicago, Illinois, United States

Livonia, Michigan, United States

Saint Joseph, Michigan, United States

Chippewa Falls, Wisconsin, United States

Canton, Illinois, United States

Carthage, Illinois, United States

Eureka, Illinois, United States

Kewanee, Illinois, United States

Macomb, Illinois, United States

Peru, Illinois, United States

Princeton, Illinois, United States

Springfield, Illinois, United States

Niles, Michigan, United States

Joplin, Missouri, United States

Fort Smith, Arkansas, United States

Bloomington, Illinois, United States

Pekin, Illinois, United States

Liberal, Kansas, United States

Bolivar, Missouri, United States

Branson, Missouri, United States

Saint Louis, Missouri, United States

Saint Louis, Missouri, United States

Peoria, Illinois, United States

Bloomington, Illinois, United States

Arroyo Grande, California, United States

Jefferson City, Missouri, United States

Oklahoma City, Oklahoma, United States

Rolla, Missouri, United States

Rolla, Missouri, United States

Springfield, Illinois, United States

Las Vegas, Nevada, United States

Newark, Delaware, United States

Newark, Delaware, United States

Newark, Delaware, United States

Wilmington, Delaware, United States

Manhattan, Kansas, United States

Henderson, Nevada, United States

Las Vegas, Nevada, United States

Las Vegas, Nevada, United States

Las Vegas, Nevada, United States

Las Vegas, Nevada, United States

Las Vegas, Nevada, United States

Las Vegas, Nevada, United States

Las Vegas, Nevada, United States

Las Vegas, Nevada, United States

Las Vegas, Nevada, United States

Carbondale, Illinois, United States

Centralia, Illinois, United States

Decatur, Illinois, United States

O'fallon, Illinois, United States

Ottawa, Illinois, United States

Bonne Terre, Missouri, United States

Sainte Genevieve, Missouri, United States

Sullivan, Missouri, United States

Sunset Hills, Missouri, United States

Oxford, Mississippi, United States

Gig Harbor, Washington, United States

Bainbridge Island, Washington, United States

Federal Way, Washington, United States

Lynnwood, Washington, United States

New Haven, Connecticut, United States

Springfield, Illinois, United States

Aurora, Colorado, United States

Pekin, Illinois, United States

Grand Rapids, Michigan, United States

Muskegon, Michigan, United States

Ann Arbor, Michigan, United States

Stevens Point, Wisconsin, United States

Minocqua, Wisconsin, United States

Sunset Hills, Missouri, United States

Niles, Michigan, United States

Reed City, Michigan, United States

Saint Joseph, Michigan, United States

Grand Rapids, Michigan, United States

Saint Joseph, Michigan, United States

Jefferson City, Missouri, United States

Kalamazoo, Michigan, United States

Mount Vernon, Illinois, United States

Patients applied

0 patients applied

Trial Officials

James H Doroshow

Principal Investigator

National Cancer Institute (NCI)

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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