Mannitol Cream for Post Herpetic Neuralgia

Launched by UNIVERSITY OF BRITISH COLUMBIA · Jun 24, 2015

Keywords

ClinConnect Summary

Pain levels: 0 to 10 Numerical Rating Scale (NRS), medication and alcohol intake will be checked daily for one week prior to randomization in 20 participants with post herpetic neuralgia, lasting more than three months. Following this 10 will be randomized to apply 30% mannitol in vehicle cream and 10 to apply vehicle cream alone for one week during which daily pain levels and use of medication and alcohol will be measured together with the mode of application (rubbing in or applying it to cling wrap then applying the cream coated cling wrap to the skin in cases of severe allodynia). After ...

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• • 1. - Suffering from post-herpetic neuralgia on the trunk or the extremities for at least three months.
• • 2. - Maximum daily pain score greater than or equal to 5/10.
• • 3. - Having failed to improve with at least one neuropathic pain medication.
• • 4- Able and willing to fill a fluid survey NRS pain scale and a medication intake questionnaire daily, preferably online but on paper, if unable, for the first 24 days of the study, then once a month for three months..
• • 5 - Preferably have access to someone who can apply cream to their back if they have pain in the back and cannot reach the area.
• • 6 - If that is not possible, ability to apply the cream to their own back, using an applicator which will be supplied.
• Exclusion Criteria:
• • 1. Allergies to any of the ingredients of the cream
• • 2. Open lesions or abrasions on the skin where the cream will be applied
• • 3. Using corticosteroids
• • 4. Unwilling to stop using other topical products (creams or patches) for the treatment of post-herpetic neuralgia
• • 5. Pregnant, breast-feeding or not using birth control
• • 6. Suffering from severe chronic pain from a cause other than post-herpetic neuralgia
• • -