ANI and SPI Guided Intraoperative Analgesia
Launched by UNIVERSITY HOSPITAL HRADEC KRALOVE · Jul 1, 2015
Trial Information
Current as of August 11, 2025
Completed
Keywords
ClinConnect Summary
The Surgical Pleth Index (SPI) and ANI (Analgesia Nociception Index) has been developed for monitoring of adequacy of analgesia during surgery.
The investigators want to compare anesthesiologist guided intraoperative analgesia with intraoperative analgesia guieded by ANI or SPI.
The following hypotheses have been made:
1. Anesthesiologist guided analgesia will result in lower surgical stress
2. Anesthesiologist guided analgesia will result in more hemodynamic stability and faster recovery of the patient after anesthesia
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients undergoing scheduled neurosurgical procedures under general anesthesia
- • GCS 15
- • ASA physical status I - III
- • elective procedures with estimated duration 1 - 3 hours
- Exclusion Criteria:
- • Presence of non-sinus rhythm
- • pacemaker
- • planned postoperative ventilation
- • procedures with planned awake intervals
- • chronic pain with opioid medication
- • opioid addiction
- • epidural administration of local anaesthetic in combination with opioid
- • corticosteroid use
- • hormonal contraception
- • chronic respiratory disease with known respiratory failure
About University Hospital Hradec Kralove
University Hospital Hradec Králové is a leading academic medical center in the Czech Republic, renowned for its commitment to advancing healthcare through innovative research and clinical trials. As a prominent sponsor of clinical studies, the hospital integrates cutting-edge medical practices with rigorous scientific inquiry, fostering collaborations that enhance patient care and treatment outcomes. With a multidisciplinary team of experts, state-of-the-art facilities, and a strong emphasis on ethical standards and patient safety, University Hospital Hradec Králové plays a pivotal role in translating research findings into practical applications that benefit the broader medical community.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Hradec Kralove, , Czechia
Patients applied
Trial Officials
Vlasta Dostalova, MD, PhD
Principal Investigator
University Hospital Hradec Kralove
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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