Predictors of Persistent Peanut Allergy at Age 5 Years

Launched by UNIVERSITY OF MANITOBA · Jul 9, 2015

Keywords

ClinConnect Summary

Introduction:

Food allergy has reached epidemic levels in Canada and peanut allergy is the most prevalent and one of the more persistent food allergies among Canadian children and adults. Avoidance or later introduction of peanut has been proposed as a possible cause of the increased rates of peanut sensitization and allergy. Although delaying the introduction of peanut into children's diets is no longer recommended, many parents continue to worry about introducing peanut and some will not introduce peanut into their child's diet without a negative skin prick test to peanut. However, some ...

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Eligibility criteria

• Challenge Inclusion Criteria:
• • CHILD study participants will be eligible for challenge if they
• • 1. Have completed their 5-year-old CHILD Study visit
• • 2. Are or have been sensitized to peanut i.e. have had a positive skin prick test (wheal diameter at least 2 mm greater than the negative control) and/or allergen-specific IgE level (\>0.35 kU/L) to peanut at their 1-, 3- and/or 5-year-old CHILD study visit
• • 3. Are not eating peanut. Children who eat less than 8-10 g of peanut per month or who eat only foods that 'may contain' traces of peanut will still be eligible for inclusion.
• Challenge Exclusion Criteria:
• • CHILD study participants will be ineligible for challenge if
• • 1. They have never had a positive skin prick test or allergen-specific IgE level to peanut
• • 2. They are eating 8-10 g of peanut at least once per month, despite having had a positive skin prick test or allergen-specific IgE level to peanut
• • 3. Their family has declined to participate
• • 4. They have a peanut skin prick test wheal size \>8mm and/or a peanut-specific IgE \>15 kU/L and a history suggestive of an IgE-mediated allergic reaction to peanut.
• • 5. They have a history of anaphylaxis to peanut or a challenge-proven diagnosis of peanut allergy within the past 1-2 years.
• • 6. They have uncontrolled asthma or any other contraindication to performing a DBPC food challenge on the day of challenge. These children may be rescheduled if their asthma control improves.
• Blood Draw Inclusion Criteria:
• • CHILD study participants will be eligible for blood draw if they
• • 1. Have completed their 5-year-old CHILD Study visit
• • 2. Are or have been sensitized to peanut i.e. have had a positive skin prick test (wheal diameter at least 2 mm greater than the negative control) and/or allergen-specific IgE level (\>0.35 kU/L) to peanut at their 1-, 3- and/or 5-year-old CHILD study visit
• Blood Draw Exclusion Criteria:
• • CHILD study participants will be ineligible for blood draw if
• • 1. They have never had a positive skin prick test or allergen-specific IgE level to peanut
• • 2. Their family has declined to participate
• • Immunological analyses of the blood samples are underway now that the 2 sites participating in this portion of the study (University of Manitoba and University of British Columbia) have completed their challenges. Challenges were halted in the spring.