Gingival Crevicular Fluid Vaspin and Omentin Levels in Type 2 Diabetic Patients With Chronic Periodontitis

Launched by BULENT ECEVIT UNIVERSITY · Sep 8, 2015

Keywords

ClinConnect Summary

Adipose tissue produces and releases a variety of inflammatory factors, including adipocytokines , such as adiponectin, leptin, tumor-necrosis factor alpha (TNF-α), interleukin-6 (IL-6), visfatin, vaspin and omentin.These adipokines have widespread effects on carbohydrate and lipid metabolism and appear to play an important role in the pathogenesis of insulin resistance, diabetes, inflammation, wound healing, and immune responses.Recently, studies evaluated the serum vaspin and omentin levels as inflammatory markers in T2DM patients. Based on the above mentioned studies, the present investi...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diabetic subjects should have T2DM and had no any known systemic diseases other than T2DM
• • Subjects who had HbA1c levels \< 8% and ≥ 6.5% (well and moderate control)
• • Chronic periodontitis patients had radiographic evidence of bone loss and attachment loss with a minimum of 6 teeth having pocket probing depth (PD) ≥ 5mm in at least 2 different quadrants
• • Control groups were designed as healthy if the full-mouth probing depth (PD) was ≤3mm and bleeding on probing (BOP) score \< %15 at examination and they had no radiographic evidence of alveolar bone loss.
• Exclusion Criteria:
• • Presence of other systemic disorders that could influence the course of periodontal disease; pregnancy, lactation, current and former use of tobacco;
• • Administration of non-steroidal and anti-inflammatory drugs or antibiotic therapies within the previous 6 months;
• • Need for antibiotic prophylaxis for dental treatment and having received non-surgical periodontal treatment within the past 6 months or surgical periodontal treatment within the past 12 months.
• • Subjects who had body mass index (BMI) \>24.9 kg /m2