Letrozole Versus Clomiphene Citrate for Ovulation Induction in Women With Poly Cystic Ovary Syndrome ( PCOS )

Launched by MOSTAFA GOMAA HAMID HALAWA · Sep 15, 2015

Keywords

ClinConnect Summary

The aim of this study is to compare the efficacy of letrozole on ovulation induction to that of clomiphene citrate in women suffering polycystic ovary syndrome.

Research question:

In women with PCOS , dose letrozole effective in ovulation induction as clomiphene citrate?

Researcher hypothesis:

In women with pcos , letrozole may be as effective as clomiphene citrate in ovulation induction.

Patients and methods Site: this study will be recruited from women attending infertility outpatient clinic at Ain Shams university maternity hospital.

Design: Randomized controlled trial.

Study popu...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Age between 20-35
• • 2. Primary or secondary infertility
• • 3. Patients diagnosed as PCOs according to Rotterdam criteria (Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group.,2003)
• Exclusion Criteria:
• Any patients have any causes of infertility other than which mentioned in the inclusion criteria as:
• • 1. Hyperprolactinemia.
• • 2. Male factor of infertility.
• WHO Guidelines 2010 for Normal seminal fluid analysis :
• • Volume\> 1.5 ml
• • ph 7.2 to 8.0
• • Liquefaction time 20 to 30 min
• • Sperms concentration \>15 million/ml
• • Total motility 40%(Progressive motility + non progressive motility)
• • Progressive motility 32%
• • Morphology \> 4% normal forms
• • 3. Thyroid dysfunction.
• • 4. Diabetes Mellitus.
• • 5. Known or suspicious tubal factor infertility by HSG or laparoscope.
• • 6. Endometrioses or pelvic inflammatory diseases .