Creatine for Depressed Male and Female Methamphetamine Users

Launched by MONTANA STATE UNIVERSITY · Oct 2, 2015

Keywords

ClinConnect Summary

This clinical trial is looking at whether a supplement called creatine can help reduce depression and anxiety in people who use methamphetamine. Researchers want to find out if creatine can not only improve mood but also lower the use of methamphetamine among both men and women. The trial is currently recruiting participants who are between the ages of 18 and 74 and have a diagnosis of methamphetamine dependence along with significant symptoms of depression and anxiety.

To be eligible for the study, participants must have a primary diagnosis of methamphetamine dependence and also meet certain criteria for depression and anxiety. For instance, they should have a specific score on depression and anxiety scales, and if they are already taking medication for these issues, their treatment should be stable for at least four weeks before starting the trial. Participants will receive creatine during the study, and the researchers will monitor its effects on both their mood and methamphetamine use. It’s important to note that individuals with certain medical conditions or who are pregnant cannot participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Current primary diagnosis of methamphetamine dependence or abuse, with methamphetamine preferred drug of abuse
• • Current diagnosis of major depressive disorder (primary or substance-induced)
• • Current diagnosis of an anxiety disorder (primary or substance-induced)
• • Current Hamilton Depression Rating scale score \> or = to 16
• • Current Hamilton Anxiety Scale score \> = to 18
• • If taking a psychotropic medication for depressed or anxious mood, regimen must be stable for \> = to 4 weeks prior to creatine treatment initiation
• Exclusion Criteria:
• • Persons unable to provide adequate informed consent
• • Persons who are at clinically significant suicidal or homicidal risk
• • Primary substance-related diagnosis other than methamphetamine dependence or abuse
• • Positive pregnancy test (females only)
• • History of renal disease
• • Clinically significant medical or neurological illness identified by history, physical exam and laboratory testing
• • History of hypersensitivity reaction to creatine