Pain Mechanisms and Ultrasonographic Disease Activity in Psoriatic Arthritis

Launched by FREDERIKSBERG UNIVERSITY HOSPITAL · Oct 8, 2015

Keywords

ClinConnect Summary

This clinical trial is studying the pain mechanisms and inflammation in people with psoriatic arthritis (PsA), a condition that causes joint pain and skin issues. Researchers want to understand how different factors, like pain levels, other health conditions, and inflammation visible through ultrasound, affect treatment outcomes after four months of anti-rheumatic therapy. They are also comparing these findings with people who have skin psoriasis but not arthritis and healthy individuals to see how they differ.

To participate, you need to be at least 18 years old and have been diagnosed with psoriatic arthritis that involves your joints. You should be starting or switching your anti-rheumatic treatment due to active symptoms. Unfortunately, if you are pregnant, have certain neurological conditions, or have taken specific medications recently, you may not be eligible. If you join the study, you will undergo assessments that will help doctors better understand your condition and the effectiveness of treatments. Your involvement could contribute to improved care for others with similar conditions in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosed with PsA according to the CASPAR (The Classification of Psoriatic Arthritis) criteria
• • Peripheral joint involvement.
• • Minimum 18 years of age.
• • Initiating or switching anti-rheumatic treatment due to active PsA.
• • Signing a written informed consent.
• Exclusion Criteria:
• • Pregnancy
• • Peripheral neuropathy
• • Demyelinising disease
• • Recent stroke
• • Other rheumatic inflammatory diseases.
• • Oral, intra-articular or intra-muscular glucocorticoids within 3 weeks prior to baseline
• • Treatment with centrally acting analgesics (opioids, anti-depressants, anticonvulsants) within 1 week prior to baseline
• • Treatment with mild analgesics (non-steroidal anti-inflammatory drugs, acetylsalicylic acid, acetaminophen) within 24 hours prior to baseline