Circulating Tumour DNA (ctDNA) in Patients With Colorectal Cancer and the Relationship to Imaging Features of Extramural Venous Invasion

Launched by IMPERIAL COLLEGE LONDON · Oct 16, 2015

Keywords

ClinConnect Summary

This clinical trial is studying a specific type of genetic material called circulating tumor DNA (ctDNA) in patients with colorectal cancer, specifically looking at how it relates to certain imaging features of extramural venous invasion (EMVI). The goal is to better understand how ctDNA can provide information about the cancer and its behavior. This study does not involve randomization or treatment; instead, it focuses on collecting blood samples from patients who have been diagnosed with colorectal adenocarcinoma but do not have cancer that has spread to other parts of the body.

To join the study, patients must be at least 16 years old, have a confirmed diagnosis of colorectal cancer, and be eligible for surgery aimed at curing the cancer. They should not have any signs of cancer spread on their scans and must have completed a specific imaging test in the six weeks before their surgery. Participants will have two blood samples taken: one before surgery and another either during or shortly after the surgery. After that, they will be followed up annually for up to three years. This trial is currently looking for participants, and anyone interested should speak with their healthcare provider for more information.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Have a biopsy-confirmed colorectal adenocarcinoma
• • 2. Is eligible for curative surgery
• • 3. Has no metastatic disease on CT scan
• • 4. Has completed pre-operative staging scan within six weeks prior to surgery
• • 5. Have provided written informed consent to participate in the study
• • 6. Be aged 16 years or over
• Exclusion Criteria:
• • 1. Have metastatic disease (including resectable liver metastases)
• • 2. Have a synchronous second malignancy
• • 3. Are contraindicated for any imaging able to determine EMVI status