The Effects of Early and Late Injection of Botulinum Toxin Type A on Upper Limb Function in Patients With Stroke

Launched by NATIONAL CHENG-KUNG UNIVERSITY HOSPITAL · Oct 18, 2015

Keywords

ClinConnect Summary

This clinical trial is studying the effects of using a treatment called OnabotulinumtoxinA (often known as Botox) on improving the movement and function of the arm in patients who have had a stroke. The researchers want to find out if giving this treatment early after a stroke is more helpful than giving it later. They are currently looking for participants between the ages of 18 and 80 who have experienced a stroke affecting one side of their body and have developed muscle stiffness (known as spasticity) as a result.

To be part of this study, patients must not have had any other conditions that affected their arm function before the stroke, and they should not be taking other medications for muscle stiffness. Participants can expect to receive the treatment and be monitored for its effects on their arm function. It’s important to note that pregnant women or those who might become pregnant cannot participate, and individuals with certain muscle-related disorders or allergies to this treatment are also excluded. If you're interested in helping advance our understanding of stroke recovery, this trial might be a good opportunity.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • stroke affecting one body side
• • spasticity develops after stroke
• Exclusion Criteria:
• • musculoskeletal conditions that affected upper limb function prior to stroke
• • concurrent use of anti-spasticity medications
• • patients with neuromuscular junction or myopathic disorders such as myasthenia gravis or others
• • patients with a known allergy to any onabotulinumtoxinA or to any of the excipients of onabotulinumtoxinA (such as human serum albumin)
• • patients who are pregnant or may become pregnant at the time of the proposed injection