The Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic Rhinosinusitis and Recurrent Sinusitis

Launched by MAHIDOL UNIVERSITY · Oct 20, 2015

Keywords

ClinConnect Summary

Chronic rhinosinusitis (CRS) is characterized by symptoms \> 12 weeks.Two or more symptoms one of which should be either nasal blockage /obstruction/congestion or nasal discharge (anterior/posterior nasal drip): facial pain/pressure reduction or loss of smell).

Mainstay of treatment are medical and surgical treatment ( ATB, adenoidectomy, ESS) Adjunctive treatment : normal saline nasal irrigation, nasal corticosteroids, nasal decongestants, mucolytics. Nasal lavage with Mupirocin represent an effective and well tolerated alternative treatment of surgically recalcitrant chronic rhinosinusit...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Chronic rhinosinusitis and/or recurrent acute/subacute sinusitis patients who were followed in pediatrics allergy clinic at Siriraj hospital between December 4, 2012, and December 3, 2016
• Exclusion Criteria:
• • 1. Patients who used antibiotic prophylaxis within within 1 year before and 6 months after started gentamicin nasal irrigation
• • 2. Patients received IVIG within 1 year before and 6 months after started gentamicin nasal irrigation
• • 3. Patients received IT within 1 year before and 6 months after started gentamicin nasal irrigation
• • 4. Patients underwent endoscopic sinus surgery within 1 year before and 6 months after started gentamicin nasal irrigation
• • 5. Patient who have mental retardation
• • 6. Patient who have aminoglycosides hypersensitivity reactions
• • 7. Pregnancy women and Lactation period
• • 8. Patient who have abnormal hearing test before started gentamicin nasal irrigation
• • 9. Patient who have chronic rhinosinusitis with nasal polyp