Low-Flow CO2 Removal for Mild to Moderate ARDS With PRISMALUNG

Launched by GROUPE HOSPITALIER PITIE-SALPETRIERE · Nov 13, 2015

Keywords

ClinConnect Summary

Extracorporeal CO2 removal (ECCO2R) with a low-flow CO2 removal device (Prismalung, Gambro-Baxter) integrated on the Prismaflex platform (Gambro-Baxter) allows tidal volume (Vt) and plateau pressure reduction in patients with mild to moderate ARDS. This pilot observational study will assess changes in pH /PaO2 /PaCO2, Respiratory Rate and device CO2 clearance in the first 24 hours of ECCO2R following Vt and plateau pressure reduction in patients with mild to moderate ARDS. Safety variables during treatment will also be analyzed. A series of 20 consecutive patients will be included in this o...

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Eligibility criteria

• Inclusion Criteria:
• • Mechanical ventilation with expected duration of \>24 hours
• • Mild to moderate Acute Respiratory Distress Syndrome (ARDS) according to the Berlin definition: 100 mmHg \<PaO2/FiO2 \<300 mmHg, with PEEP \> 5 cmH2O
• Exclusion Criteria:
• • Age \<18 years
• • Pregnancy
• • Severe hypoxemia with PaO2/FiO2 \<100 mmHg
• • Body mass index \> 40 kg/m2
• • Decompensated heart insufficiency or acute coronary syndrome
• • Severe Chronic obstructive pulmonary disease (COPD)
• • Major respiratory acidosis with PaCO2 \>60 mmHg
• • Acute brain injury
• • Severe liver insufficiency (Child-Pugh scores \>7) or fulminant hepatic failure
• • Heparin-induced thrombocytopenia
• • Contraindication for systemic anticoagulation
• • Patient moribund, decision to limit therapeutic interventions
• • Catheter access to femoral vein or jugular vein impossible
• • Pneumothorax
• • Platelet \<50 G/L
• • Lacking consent