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Search / Trial NCT02609815

Initial Combination of Gemigliptin and Metformin on Microbiota Change

Launched by SEOUL NATIONAL UNIVERSITY BUNDANG HOSPITAL · Nov 17, 2015

Trial Information

Current as of July 22, 2025

Completed

Keywords

ClinConnect Summary

Obese type 2 diabetes patients who were not treated with anti-diabetic medication within 6 weeks, were randomly assigned to gemigliptin/metformin or sulphonylurea/metformin. After 24 week treatment, gut microbiota composition change, glucose lowering effect, body weight, and gut hormones were compared between two groups.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Type 2 diabetes
  • Drug naive (no anti-diabetic medication within 6 weeks)
  • HbA1c \>= 7.5%
  • BMI \>= 25.0 kg/m2
  • Exclusion Criteria:
  • Type 1 diabetes
  • DKA, HHS
  • history of hypersensitivity to sulphonylurea, metformin or DPP-4 inhibitor
  • Gestational diabetes mellitus
  • Serum Cr \>1.5 mg/dL (male), \>1.4mg/dL (female)
  • Abnormal liver function test
  • Anti-obesity medication within 3 months
  • Gastrointestinal motility drug, laxatives within 3 months
  • History of major gastrointestinal surgery

About Seoul National University Bundang Hospital

Seoul National University Bundang Hospital is a leading academic medical center located in South Korea, renowned for its commitment to innovative research and excellence in patient care. As a sponsor of clinical trials, the hospital leverages its extensive expertise in various medical fields, employing cutting-edge technologies and methodologies to advance healthcare solutions. With a multidisciplinary team of skilled researchers and clinicians, the hospital aims to enhance clinical outcomes through rigorous investigation and collaboration, contributing significantly to the global medical community and improving patient lives.

Locations

Seongnam, Gyeonggi, Korea, Republic Of

Patients applied

0 patients applied

Trial Officials

Tae Jung Oh

Study Director

Seoul National University Bundang Hospital

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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