Initial Combination of Gemigliptin and Metformin on Microbiota Change
Launched by SEOUL NATIONAL UNIVERSITY BUNDANG HOSPITAL · Nov 17, 2015
Trial Information
Current as of July 25, 2025
Completed
Keywords
ClinConnect Summary
Obese type 2 diabetes patients who were not treated with anti-diabetic medication within 6 weeks, were randomly assigned to gemigliptin/metformin or sulphonylurea/metformin. After 24 week treatment, gut microbiota composition change, glucose lowering effect, body weight, and gut hormones were compared between two groups.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Type 2 diabetes
- • Drug naive (no anti-diabetic medication within 6 weeks)
- • HbA1c \>= 7.5%
- • BMI \>= 25.0 kg/m2
- Exclusion Criteria:
- • Type 1 diabetes
- • DKA, HHS
- • history of hypersensitivity to sulphonylurea, metformin or DPP-4 inhibitor
- • Gestational diabetes mellitus
- • Serum Cr \>1.5 mg/dL (male), \>1.4mg/dL (female)
- • Abnormal liver function test
- • Anti-obesity medication within 3 months
- • Gastrointestinal motility drug, laxatives within 3 months
- • History of major gastrointestinal surgery
About Seoul National University Bundang Hospital
Seoul National University Bundang Hospital is a leading academic medical center located in South Korea, renowned for its commitment to innovative research and excellence in patient care. As a sponsor of clinical trials, the hospital leverages its extensive expertise in various medical fields, employing cutting-edge technologies and methodologies to advance healthcare solutions. With a multidisciplinary team of skilled researchers and clinicians, the hospital aims to enhance clinical outcomes through rigorous investigation and collaboration, contributing significantly to the global medical community and improving patient lives.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Seongnam, Gyeonggi, Korea, Republic Of
Patients applied
Trial Officials
Tae Jung Oh
Study Director
Seoul National University Bundang Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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