Rod and Cone Mediated Function in Retinal Disease

Launched by NATIONAL EYE INSTITUTE (NEI) · Nov 28, 2015

Keywords

ClinConnect Summary

This clinical trial is studying how well people can see in the dark and whether this can help doctors understand the severity of certain eye diseases, like retinal degeneration, retinitis pigmentosa, and Stargardt's disease. The goal is to see if measuring night vision can detect these diseases early and track how they change over time. Researchers are looking for individuals aged 5 and older, including those with retinal diseases and healthy volunteers who can see well (20/20 vision or better in at least one eye).

Participants will go through a detailed screening process that includes eye exams, imaging tests, and special vision tests to assess how their eyes respond to light. The first visit will take several hours, and there may be up to six more visits over the next year. During these visits, participants will undergo various tests, including sitting in the dark to measure their sensitivity to light. It’s important for participants to understand what the study involves and be able to cooperate with the testing. This study aims to improve our understanding of retinal diseases and how they affect vision.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • Participant must be five years of age or older.
• • Participant (or legal guardian) must understand and sign the protocol s informed consent document.
• • Participant must be able to cooperate with the testing required for this study.
• For Participants with retinal disease only:
• • Participant must have retinal disease, defined as evidence of loss of retinal dysfunction and/or degeneration as established by standard clinical methods including perimetry, ERG and imaging.
• • Participant must have a measurable visual acuity.
• For Healthy Volunteers only:
• • -Participant must have visual acuity of 20/20 or better, with or without correction (e.g., glasses or contact lens) in at least one eye.
• EXCLUSION CRITERIA:
• • -Participant with changes in pre-retinal media sufficient to obscure a view of the retina.